DegronMD - Q6B0B8(TIGD3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P371T	TCGA-22-1016	LUSC	TCGA	PGKTPPSS	DEG_SCF_FBW7_1	367:374	Mutation altering degron motif	0.7031
p.P371T	DO26971	LUSC	ICGC	PGKTPPSS	DEG_SCF_FBW7_1	367:374	Mutation altering degron motif	0.7031
p.G368C	TCGA-55-7995	LUAD	TCGA	PGKTPPSS	DEG_SCF_FBW7_1	367:374	Mutation altering degron motif	0.6489
p.G368C	DO45323	LUAD	ICGC	PGKTPPSS	DEG_SCF_FBW7_1	367:374	Mutation altering degron motif	0.6489
p.G364V	TCGA-CV-A461	HNSC	TCGA	PGKTPPSS	DEG_SCF_FBW7_1	367:374	Mutation rewiring degron network	0.25
p.G364V	DO49058	HNSC	ICGC	PGKTPPSS	DEG_SCF_FBW7_1	367:374	Mutation rewiring degron network	0.25
p.G368S	TCGA-DG-A2KK	CESC	TCGA	PGKTPPSS	DEG_SCF_FBW7_1	367:374	Mutation altering degron motif	0.5882
p.G368S	TCGA-GN-A4U4	SKCM	TCGA	PGKTPPSS	DEG_SCF_FBW7_1	367:374	Mutation altering degron motif	0.5882
p.G368S	DO51595	CESC	ICGC	PGKTPPSS	DEG_SCF_FBW7_1	367:374	Mutation altering degron motif	0.5882
p.G368S	DO51256	SKCM	ICGC	PGKTPPSS	DEG_SCF_FBW7_1	367:374	Mutation altering degron motif	0.5882
p.S359R	DO222884	COCA	ICGC	PGKTPPSS	DEG_SCF_FBW7_1	367:374	Mutation rewiring degron network	0.1111
p.S358I	DO229022	LICA	ICGC	PGKTPPSS	DEG_SCF_FBW7_1	367:374	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons