DegronMD

Uniprot ID: Q6B0B8

Source protein: Tigger transposable element-derived protein 3

Source gene: TIGD3

Class: DEG_SCF_FBW7_1

Location: 367:374

E3 ligase: FBXW7

DEGRON score: 0.7231

ASA_SCORE: 86.425

COIL: 0.9314

CONS_SCORE: 0.3408

DSS_SCORE: 0.6499

HELIX: 0.0486

FCONS_SCORE: 0.9192

RIG_SCORE: 0.5411

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P371T	TCGA-22-1016	LUSC	TCGA	PGKTPPSS	DEG_SCF_FBW7_1	0.7031
p.P371T	DO26971	LUSC	ICGC	PGKTPPSS	DEG_SCF_FBW7_1	0.7031
p.G368C	TCGA-55-7995	LUAD	TCGA	PGKTPPSS	DEG_SCF_FBW7_1	0.6489
p.G368C	DO45323	LUAD	ICGC	PGKTPPSS	DEG_SCF_FBW7_1	0.6489
p.G364V	TCGA-CV-A461	HNSC	TCGA	PGKTPPSS	DEG_SCF_FBW7_1	0.25
p.G364V	DO49058	HNSC	ICGC	PGKTPPSS	DEG_SCF_FBW7_1	0.25
p.G368S	TCGA-DG-A2KK	CESC	TCGA	PGKTPPSS	DEG_SCF_FBW7_1	0.5882
p.G368S	TCGA-GN-A4U4	SKCM	TCGA	PGKTPPSS	DEG_SCF_FBW7_1	0.5882
p.G368S	DO51595	CESC	ICGC	PGKTPPSS	DEG_SCF_FBW7_1	0.5882
p.G368S	DO51256	SKCM	ICGC	PGKTPPSS	DEG_SCF_FBW7_1	0.5882
p.S359R	DO222884	COCA	ICGC	PGKTPPSS	DEG_SCF_FBW7_1	0.1111
p.S358I	DO229022	LICA	ICGC	PGKTPPSS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6B0B8	Tigger transposable element-derived protein 3	DEG_SCF_FBW7_1	367:374	PGKTPPSS	FBXW7	0.7231	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons