DegronMD - Q6DKI7(PVRIG)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P300T	TCGA-AO-A03T	BRCA	TCGA	LTLFPD	LIG_APCC_ABBA_1	307:312	Mutation rewiring degron network	0.1389
p.P300T	DO3215	BRCA	ICGC	LTLFPD	LIG_APCC_ABBA_1	307:312	Mutation rewiring degron network	0.1389
p.P311T	TCGA-B5-A0JZ	UCEC	TCGA	LTLFPD	LIG_APCC_ABBA_1	307:312	Mutation altering degron motif	0.5919
p.P311T	DO42761	UCEC	ICGC	LTLFPD	LIG_APCC_ABBA_1	307:312	Mutation altering degron motif	0.5919
p.P311S	TCGA-BF-AAOX	SKCM	TCGA	LTLFPD	LIG_APCC_ABBA_1	307:312	Mutation altering degron motif	0.5641
p.P311S	DO223907	SKCM	ICGC	LTLFPD	LIG_APCC_ABBA_1	307:312	Mutation altering degron motif	0.5641
p.G306D	TCGA-FI-A2D0	UCEC	TCGA	LTLFPD	LIG_APCC_ABBA_1	307:312	Mutation rewiring degron network	0.3056
p.G306D	DO43891	UCEC	ICGC	LTLFPD	LIG_APCC_ABBA_1	307:312	Mutation rewiring degron network	0.3056
p.G306D	ACH-001369	Ovarian Cancer	CCLE	LTLFPD	LIG_APCC_ABBA_1	307:312	Mutation rewiring degron network	0.3056
p.L309R	TCGA-MX-A5UJ	STAD	TCGA	LTLFPD	LIG_APCC_ABBA_1	307:312	Mutation altering degron motif	0.8428
p.L309R	DO48547	STAD	ICGC	LTLFPD	LIG_APCC_ABBA_1	307:312	Mutation altering degron motif	0.8428
p.G306S	DO234246	ESAD	ICGC	LTLFPD	LIG_APCC_ABBA_1	307:312	Mutation rewiring degron network	0.3056
p.G304C	DO229022	LICA	ICGC	LTLFPD	LIG_APCC_ABBA_1	307:312	Mutation rewiring degron network	0.25
p.G304C	DO229031	LICA	ICGC	LTLFPD	LIG_APCC_ABBA_1	307:312	Mutation rewiring degron network	0.25
p.G297V	DO229025	LICA	ICGC	LTLFPD	LIG_APCC_ABBA_1	307:312	Mutation rewiring degron network	0.0556
p.R314Q	DO27937	ORCA	ICGC	LTLFPD	LIG_APCC_ABBA_1	307:312	Mutation rewiring degron network	0.2778
p.R299G	ACH-000947	Ovarian Cancer	CCLE	LTLFPD	LIG_APCC_ABBA_1	307:312	Mutation rewiring degron network	0.1111
p.R299G	OVK-18	ovary	COSMIC	LTLFPD	LIG_APCC_ABBA_1	307:312	Mutation rewiring degron network	0.1111
p.R317K	ACH-002446	Gastric Cancer	CCLE	LTLFPD	LIG_APCC_ABBA_1	307:312	Mutation rewiring degron network	0.1944

Kaplan plot for PVRIG in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PVRIG

UniProt ID: Q6DKI7

Entrez ID: 79037

Protein name: Transmembrane protein PVRIG (CD112 receptor) (CD112R) (Poliovirus receptor-related immunoglobulin domain-containing protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PVRIG in