DegronMD

Uniprot ID: Q6DKI7

Source protein: Transmembrane protein PVRIG

Source gene: PVRIG

Class: LIG_APCC_ABBA_1

Location: 307:312

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9396

ASA_SCORE: 66.8

COIL: 0.767

CONS_SCORE: 1

DSS_SCORE: 0.7106

HELIX: 0.0343

FCONS_SCORE: 1

RIG_SCORE: 0.699

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P300T	TCGA-AO-A03T	BRCA	TCGA	LTLFPD	LIG_APCC_ABBA_1	0.1389
p.P300T	DO3215	BRCA	ICGC	LTLFPD	LIG_APCC_ABBA_1	0.1389
p.P311T	TCGA-B5-A0JZ	UCEC	TCGA	LTLFPD	LIG_APCC_ABBA_1	0.5919
p.P311T	DO42761	UCEC	ICGC	LTLFPD	LIG_APCC_ABBA_1	0.5919
p.P311S	TCGA-BF-AAOX	SKCM	TCGA	LTLFPD	LIG_APCC_ABBA_1	0.5641
p.P311S	DO223907	SKCM	ICGC	LTLFPD	LIG_APCC_ABBA_1	0.5641
p.G306D	TCGA-FI-A2D0	UCEC	TCGA	LTLFPD	LIG_APCC_ABBA_1	0.3056
p.G306D	DO43891	UCEC	ICGC	LTLFPD	LIG_APCC_ABBA_1	0.3056
p.G306D	ACH-001369	Ovarian Cancer	CCLE	LTLFPD	LIG_APCC_ABBA_1	0.3056
p.L309R	TCGA-MX-A5UJ	STAD	TCGA	LTLFPD	LIG_APCC_ABBA_1	0.8428
p.L309R	DO48547	STAD	ICGC	LTLFPD	LIG_APCC_ABBA_1	0.8428
p.G306S	DO234246	ESAD	ICGC	LTLFPD	LIG_APCC_ABBA_1	0.3056
p.G304C	DO229022	LICA	ICGC	LTLFPD	LIG_APCC_ABBA_1	0.25
p.G304C	DO229031	LICA	ICGC	LTLFPD	LIG_APCC_ABBA_1	0.25
p.G297V	DO229025	LICA	ICGC	LTLFPD	LIG_APCC_ABBA_1	0.0556
p.R314Q	DO27937	ORCA	ICGC	LTLFPD	LIG_APCC_ABBA_1	0.2778
p.R299G	ACH-000947	Ovarian Cancer	CCLE	LTLFPD	LIG_APCC_ABBA_1	0.1111
p.R299G	OVK-18	ovary	COSMIC	LTLFPD	LIG_APCC_ABBA_1	0.1111
p.R317K	ACH-002446	Gastric Cancer	CCLE	LTLFPD	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6DKI7	Transmembrane protein PVRIG	LIG_APCC_ABBA_1	307:312	LTLFPD	APC,CDC20,FZR1	0.9396	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons