DegronMD - Q6DKJ4(NXN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E87K	TCGA-06-5416	GBM	TCGA	PRRRLEIVF	DEG_APCC_DBOX_1	82:90	Mutation altering degron motif	0.591
p.E87K	DO10880	GBM	ICGC	PRRRLEIVF	DEG_APCC_DBOX_1	82:90	Mutation altering degron motif	0.591
p.R98L	TCGA-GN-A265	SKCM	TCGA	PRRRLEIVF	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.1111
p.R98L	DO37491	SKCM	ICGC	PRRRLEIVF	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.1111
p.P80S	DO44153	BRCA	ICGC	PRRRLEIVF	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.2778
p.A93V	DO223732	CESC	ICGC	PRRRLEIVF	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.25
p.D100G	DO8842	COAD	ICGC	PRRRLEIVF	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.0556
p.L82I	DO222809	COCA	ICGC	PRRRLEIVF	DEG_APCC_DBOX_1	82:90	Mutation altering degron motif	0.7174
p.Q73K	DO228948	LICA	ICGC	PRRRLEIVF	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.0833
p.A74P	DO30090	OV	ICGC	PRRRLEIVF	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.1111
p.R74Q	DO37679	SKCM	ICGC	PRRRLEIVF	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.1111
p.N73I	DO42177	UCEC	ICGC	PRRRLEIVF	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.0833
p.A72V	DO41331	UCEC	ICGC	PRRRLEIVF	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.0556
p.R98Q	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	PRRRLEIVF	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.1111
p.R98Q	ACH-002221	Lymphoma	CCLE	PRRRLEIVF	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.1111
p.E79G	ACH-000091	Ovarian Cancer	CCLE	PRRRLEIVF	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.25
p.D85E	WM278	skin	COSMIC	PRRRLEIVF	DEG_APCC_DBOX_1	82:90	Mutation altering degron motif	0.6758
p.S77F	HT-115	large intestine	COSMIC	PRRRLEIVF	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.1944
p.C97Y	SNU-175	large intestine	COSMIC	PRRRLEIVF	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.1389
p.G90R	HCC1500	breast	COSMIC	PRRRLEIVF	DEG_APCC_DBOX_1	82:90	Mutation altering degron motif	0.7568
p.Y91D	H3255	lung	COSMIC	PRRRLEIVF	DEG_APCC_DBOX_1	82:90	Mutation rewiring degron network	0.3056

Kaplan plot for NXN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NXN

UniProt ID: Q6DKJ4

Entrez ID: 64359

Protein name: Nucleoredoxin (EC 1.8.1.8)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NXN in