DegronMD

Uniprot ID: Q6DKJ4

Source protein: Nucleoredoxin

Source gene: NXN

Class: DEG_APCC_DBOX_1

Location: 82:90

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8795

ASA_SCORE: 57.1111

COIL: 0.3664

CONS_SCORE: 0.4106

DSS_SCORE: 0.4722

HELIX: 0.0902

FCONS_SCORE: 1.3079

RIG_SCORE: 0.7954

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E87K	TCGA-06-5416	GBM	TCGA	PRRRLEIVF	DEG_APCC_DBOX_1	0.591
p.E87K	DO10880	GBM	ICGC	PRRRLEIVF	DEG_APCC_DBOX_1	0.591
p.R98L	TCGA-GN-A265	SKCM	TCGA	PRRRLEIVF	DEG_APCC_DBOX_1	0.1111
p.R98L	DO37491	SKCM	ICGC	PRRRLEIVF	DEG_APCC_DBOX_1	0.1111
p.P80S	DO44153	BRCA	ICGC	PRRRLEIVF	DEG_APCC_DBOX_1	0.2778
p.A93V	DO223732	CESC	ICGC	PRRRLEIVF	DEG_APCC_DBOX_1	0.25
p.D100G	DO8842	COAD	ICGC	PRRRLEIVF	DEG_APCC_DBOX_1	0.0556
p.L82I	DO222809	COCA	ICGC	PRRRLEIVF	DEG_APCC_DBOX_1	0.7174
p.Q73K	DO228948	LICA	ICGC	PRRRLEIVF	DEG_APCC_DBOX_1	0.0833
p.A74P	DO30090	OV	ICGC	PRRRLEIVF	DEG_APCC_DBOX_1	0.1111
p.R74Q	DO37679	SKCM	ICGC	PRRRLEIVF	DEG_APCC_DBOX_1	0.1111
p.N73I	DO42177	UCEC	ICGC	PRRRLEIVF	DEG_APCC_DBOX_1	0.0833
p.A72V	DO41331	UCEC	ICGC	PRRRLEIVF	DEG_APCC_DBOX_1	0.0556
p.R98Q	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	PRRRLEIVF	DEG_APCC_DBOX_1	0.1111
p.R98Q	ACH-002221	Lymphoma	CCLE	PRRRLEIVF	DEG_APCC_DBOX_1	0.1111
p.E79G	ACH-000091	Ovarian Cancer	CCLE	PRRRLEIVF	DEG_APCC_DBOX_1	0.25
p.D85E	WM278	skin	COSMIC	PRRRLEIVF	DEG_APCC_DBOX_1	0.6758
p.S77F	HT-115	large_intestine	COSMIC	PRRRLEIVF	DEG_APCC_DBOX_1	0.1944
p.C97Y	SNU-175	large_intestine	COSMIC	PRRRLEIVF	DEG_APCC_DBOX_1	0.1389
p.G90R	HCC1500	breast	COSMIC	PRRRLEIVF	DEG_APCC_DBOX_1	0.7568
p.Y91D	H3255	lung	COSMIC	PRRRLEIVF	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6DKJ4	Nucleoredoxin	DEG_APCC_DBOX_1	82:90	PRRRLEIVF	APC,CDC20,FZR1	0.8795	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons