DegronMD - Q6E0U4(DMKN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G301S	TCGA-AG-A02X	READ	TCGA	DSGSESS	DEG_SCF_TRCP1_1	299:305	Mutation altering degron motif	0.6993
p.S296G	TCGA-CS-4944	LGG	TCGA	DSGSESS	DEG_SCF_TRCP1_1	299:305	Mutation rewiring degron network	0.25
p.S296G	DO22512	LGG	ICGC	DSGSESS	DEG_SCF_TRCP1_1	299:305	Mutation rewiring degron network	0.25
p.S305F	TCGA-D3-A51G	SKCM	TCGA	DSGSESS	DEG_SCF_TRCP1_1	299:305	Mutation altering degron motif	0.6871
p.S305F	DO47700	SKCM	ICGC	DSGSESS	DEG_SCF_TRCP1_1	299:305	Mutation altering degron motif	0.6871
p.G307E	TCGA-EE-A2GB	SKCM	TCGA	DSGSESS	DEG_SCF_TRCP1_1	299:305	Mutation rewiring degron network	0.2778
p.G307E	DO222683	MELA	ICGC	DSGSESS	DEG_SCF_TRCP1_1	299:305	Mutation rewiring degron network	0.2778
p.G307E	DO37417	SKCM	ICGC	DSGSESS	DEG_SCF_TRCP1_1	299:305	Mutation rewiring degron network	0.2778
p.G307R	TCGA-EE-A2MR	SKCM	TCGA	DSGSESS	DEG_SCF_TRCP1_1	299:305	Mutation rewiring degron network	0.2778
p.G307R	DO37819	SKCM	ICGC	DSGSESS	DEG_SCF_TRCP1_1	299:305	Mutation rewiring degron network	0.2778
p.R297I	TCGA-G2-A3VY	BLCA	TCGA	DSGSESS	DEG_SCF_TRCP1_1	299:305	Mutation rewiring degron network	0.2778
p.R297I	DO590	BLCA	ICGC	DSGSESS	DEG_SCF_TRCP1_1	299:305	Mutation rewiring degron network	0.2778
p.W306L	TCGA-HC-7081	PRAD	TCGA	DSGSESS	DEG_SCF_TRCP1_1	299:305	Mutation rewiring degron network	0.3056
p.W306L	DO49789	PRAD	ICGC	DSGSESS	DEG_SCF_TRCP1_1	299:305	Mutation rewiring degron network	0.3056
p.D299E	TCGA-NK-A5CT	LUSC	TCGA	DSGSESS	DEG_SCF_TRCP1_1	299:305	Mutation altering degron motif	0.6758
p.D299E	DO219209	LUSC	ICGC	DSGSESS	DEG_SCF_TRCP1_1	299:305	Mutation altering degron motif	0.6758
p.S304Y	TCGA-O2-A52V	LUSC	TCGA	DSGSESS	DEG_SCF_TRCP1_1	299:305	Mutation altering degron motif	0.6009
p.S304Y	DO219223	LUSC	ICGC	DSGSESS	DEG_SCF_TRCP1_1	299:305	Mutation altering degron motif	0.6009
p.S290R	DO229047	LICA	ICGC	DSGSESS	DEG_SCF_TRCP1_1	299:305	Mutation rewiring degron network	0.0833
p.S302R	SIDM00541	Colorectal Carcinoma	GDSC	DSGSESS	DEG_SCF_TRCP1_1	299:305	Mutation altering degron motif	0.6316
p.S302R	ACH-000926	Colon/Colorectal Cancer	CCLE	DSGSESS	DEG_SCF_TRCP1_1	299:305	Mutation altering degron motif	0.6316
p.S302R	HT55	large intestine	COSMIC	DSGSESS	DEG_SCF_TRCP1_1	299:305	Mutation altering degron motif	0.6316
p.S289L	LB2518-MEL	skin	COSMIC	DSGSESS	DEG_SCF_TRCP1_1	299:305	Mutation rewiring degron network	0.0556
p.G300C	OSC-19	upper aerodigestive tract	COSMIC	DSGSESS	DEG_SCF_TRCP1_1	299:305	Mutation altering degron motif	0.76

Kaplan plot for DMKN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DMKN

UniProt ID: Q6E0U4

Entrez ID: 93099

Protein name: Dermokine (Epidermis-specific secreted protein SK30/SK89)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DMKN in