DegronMD

Uniprot ID: Q6E0U4

Source protein: Dermokine

Source gene: DMKN

Class: DEG_SCF_TRCP1_1

Location: 299:305

E3 ligase: BTRC

DEGRON score: 0.9905

ASA_SCORE: 65.7429

COIL: 0.7749

CONS_SCORE: 0.4718

DSS_SCORE: 0.6726

HELIX: 0.1141

FCONS_SCORE: 1.1163

RIG_SCORE: 0.5188

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G301S	TCGA-AG-A02X	READ	TCGA	DSGSESS	DEG_SCF_TRCP1_1	0.6993
p.S296G	TCGA-CS-4944	LGG	TCGA	DSGSESS	DEG_SCF_TRCP1_1	0.25
p.S296G	DO22512	LGG	ICGC	DSGSESS	DEG_SCF_TRCP1_1	0.25
p.S305F	TCGA-D3-A51G	SKCM	TCGA	DSGSESS	DEG_SCF_TRCP1_1	0.6871
p.S305F	DO47700	SKCM	ICGC	DSGSESS	DEG_SCF_TRCP1_1	0.6871
p.G307E	TCGA-EE-A2GB	SKCM	TCGA	DSGSESS	DEG_SCF_TRCP1_1	0.2778
p.G307E	DO222683	MELA	ICGC	DSGSESS	DEG_SCF_TRCP1_1	0.2778
p.G307E	DO37417	SKCM	ICGC	DSGSESS	DEG_SCF_TRCP1_1	0.2778
p.G307R	TCGA-EE-A2MR	SKCM	TCGA	DSGSESS	DEG_SCF_TRCP1_1	0.2778
p.G307R	DO37819	SKCM	ICGC	DSGSESS	DEG_SCF_TRCP1_1	0.2778
p.R297I	TCGA-G2-A3VY	BLCA	TCGA	DSGSESS	DEG_SCF_TRCP1_1	0.2778
p.R297I	DO590	BLCA	ICGC	DSGSESS	DEG_SCF_TRCP1_1	0.2778
p.W306L	TCGA-HC-7081	PRAD	TCGA	DSGSESS	DEG_SCF_TRCP1_1	0.3056
p.W306L	DO49789	PRAD	ICGC	DSGSESS	DEG_SCF_TRCP1_1	0.3056
p.D299E	TCGA-NK-A5CT	LUSC	TCGA	DSGSESS	DEG_SCF_TRCP1_1	0.6758
p.D299E	DO219209	LUSC	ICGC	DSGSESS	DEG_SCF_TRCP1_1	0.6758
p.S304Y	TCGA-O2-A52V	LUSC	TCGA	DSGSESS	DEG_SCF_TRCP1_1	0.6009
p.S304Y	DO219223	LUSC	ICGC	DSGSESS	DEG_SCF_TRCP1_1	0.6009
p.S290R	DO229047	LICA	ICGC	DSGSESS	DEG_SCF_TRCP1_1	0.0833
p.S302R	SIDM00541	Colorectal Carcinoma	GDSC	DSGSESS	DEG_SCF_TRCP1_1	0.6316
p.S302R	ACH-000926	Colon/Colorectal Cancer	CCLE	DSGSESS	DEG_SCF_TRCP1_1	0.6316
p.S302R	HT55	large_intestine	COSMIC	DSGSESS	DEG_SCF_TRCP1_1	0.6316
p.S289L	LB2518-MEL	skin	COSMIC	DSGSESS	DEG_SCF_TRCP1_1	0.0556
p.G300C	OSC-19	upper_aerodigestive_tract	COSMIC	DSGSESS	DEG_SCF_TRCP1_1	0.76

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6E0U4	Dermokine	DEG_SCF_TRCP1_1	299:305	DSGSESS	BTRC	0.9905	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons