DegronMD - Q6HA08(ASTL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L64M	TCGA-39-5034	LUSC	TCGA	LEETPESS	DEG_SCF_FBW7_1	64:71	Mutation altering degron motif	0.5999
p.L64M	DO26854	LUSC	ICGC	LEETPESS	DEG_SCF_FBW7_1	64:71	Mutation altering degron motif	0.5999
p.F72L	TCGA-44-2656	LUAD	TCGA	LEETPESS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.3056
p.F72L	DO26052	LUAD	ICGC	LEETPESS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.3056
p.P56L	TCGA-EE-A183	SKCM	TCGA	LEETPESS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.1111
p.P56L	DO37715	SKCM	ICGC	LEETPESS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.1111
p.P56L	SIDM00492	Glioblastoma	GDSC	LEETPESS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.1111
p.P56L	AM-38	central nervous system	COSMIC	LEETPESS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.1111
p.E75K	TCGA-EO-A22R	UCEC	TCGA	LEETPESS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.2222
p.E75K	DO233908	GACA	ICGC	LEETPESS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.2222
p.E75K	DO42713	UCEC	ICGC	LEETPESS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.2222
p.F72C	TCGA-HU-A4GU	STAD	TCGA	LEETPESS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.3056
p.F72C	DO47849	STAD	ICGC	LEETPESS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.3056
p.E65K	DO220893	MELA	ICGC	LEETPESS	DEG_SCF_FBW7_1	64:71	Mutation altering degron motif	0.591
p.LE64LK	DO220893	MELA	ICGC	LEETPESS	DEG_SCF_FBW7_1	64:71	Mutation altering degron motif	0.7857
p.R80W	SIDM02072	Colorectal Carcinoma	GDSC	LEETPESS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.0833
p.I58F	SIDM00541	Colorectal Carcinoma	GDSC	LEETPESS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.1667
p.I58F	ACH-000926	Colon/Colorectal Cancer	CCLE	LEETPESS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.1667
p.I58F	HT55	large intestine	COSMIC	LEETPESS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.1667
p.L62I	SIDM00789	Colorectal Carcinoma	GDSC	LEETPESS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.2778
p.L62I	ACH-000997	Colon/Colorectal Cancer	CCLE	LEETPESS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.2778
p.L62I	ACH-001061	Colon/Colorectal Cancer	CCLE	LEETPESS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.2778
p.L62I	HCT-15	large intestine	COSMIC	LEETPESS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.2778
p.P81L	SIDM00007	Other Solid Cancers	GDSC	LEETPESS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.0556
p.P81L	MCC13	skin	COSMIC	LEETPESS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.0556
p.R80Q	SIDM00537	Colorectal Carcinoma	GDSC	LEETPESS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.0833
p.R80Q	ACH-000982	Colon/Colorectal Cancer	CCLE	LEETPESS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.0833
p.R80Q	ACH-001345	Colon/Colorectal Cancer	CCLE	LEETPESS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.0833
p.R80Q	GP5d	large intestine	COSMIC	LEETPESS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.0833
p.E69Q	SIDM01322	Oral Cavity Carcinoma	GDSC	LEETPESS	DEG_SCF_FBW7_1	64:71	Mutation altering degron motif	0.5633
p.E69Q	ACH-000735	Head and Neck Cancer	CCLE	LEETPESS	DEG_SCF_FBW7_1	64:71	Mutation altering degron motif	0.5633
p.I74V	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	LEETPESS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.25
p.I74V	ACH-000813	Lung Cancer	CCLE	LEETPESS	DEG_SCF_FBW7_1	64:71	Mutation rewiring degron network	0.25

Kaplan plot for ASTL in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ASTL

UniProt ID: Q6HA08

Entrez ID: 431705

Protein name: Astacin-like metalloendopeptidase (EC 3.4.-.-) (Oocyte astacin) (Ovastacin) (ZP2-proteinase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ASTL in