DegronMD

Uniprot ID: Q6HA08

Source protein: Astacin-like metalloendopeptidase

Source gene: ASTL

Class: DEG_SCF_FBW7_1

Location: 64:71

E3 ligase: FBXW7

DEGRON score: 0.7765

ASA_SCORE: 88.1875

COIL: 0.7885

CONS_SCORE: 0.3425

DSS_SCORE: 0.3743

HELIX: 0.1721

FCONS_SCORE: 0.8661

RIG_SCORE: 0.7852

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L64M	TCGA-39-5034	LUSC	TCGA	LEETPESS	DEG_SCF_FBW7_1	0.5999
p.L64M	DO26854	LUSC	ICGC	LEETPESS	DEG_SCF_FBW7_1	0.5999
p.F72L	TCGA-44-2656	LUAD	TCGA	LEETPESS	DEG_SCF_FBW7_1	0.3056
p.F72L	DO26052	LUAD	ICGC	LEETPESS	DEG_SCF_FBW7_1	0.3056
p.P56L	TCGA-EE-A183	SKCM	TCGA	LEETPESS	DEG_SCF_FBW7_1	0.1111
p.P56L	DO37715	SKCM	ICGC	LEETPESS	DEG_SCF_FBW7_1	0.1111
p.P56L	SIDM00492	Glioblastoma	GDSC	LEETPESS	DEG_SCF_FBW7_1	0.1111
p.P56L	AM-38	central_nervous_system	COSMIC	LEETPESS	DEG_SCF_FBW7_1	0.1111
p.E75K	TCGA-EO-A22R	UCEC	TCGA	LEETPESS	DEG_SCF_FBW7_1	0.2222
p.E75K	DO233908	GACA	ICGC	LEETPESS	DEG_SCF_FBW7_1	0.2222
p.E75K	DO42713	UCEC	ICGC	LEETPESS	DEG_SCF_FBW7_1	0.2222
p.F72C	TCGA-HU-A4GU	STAD	TCGA	LEETPESS	DEG_SCF_FBW7_1	0.3056
p.F72C	DO47849	STAD	ICGC	LEETPESS	DEG_SCF_FBW7_1	0.3056
p.E65K	DO220893	MELA	ICGC	LEETPESS	DEG_SCF_FBW7_1	0.591
p.LE64LK	DO220893	MELA	ICGC	LEETPESS	DEG_SCF_FBW7_1	0.7857
p.R80W	SIDM02072	Colorectal Carcinoma	GDSC	LEETPESS	DEG_SCF_FBW7_1	0.0833
p.I58F	SIDM00541	Colorectal Carcinoma	GDSC	LEETPESS	DEG_SCF_FBW7_1	0.1667
p.I58F	ACH-000926	Colon/Colorectal Cancer	CCLE	LEETPESS	DEG_SCF_FBW7_1	0.1667
p.I58F	HT55	large_intestine	COSMIC	LEETPESS	DEG_SCF_FBW7_1	0.1667
p.L62I	SIDM00789	Colorectal Carcinoma	GDSC	LEETPESS	DEG_SCF_FBW7_1	0.2778
p.L62I	ACH-000997	Colon/Colorectal Cancer	CCLE	LEETPESS	DEG_SCF_FBW7_1	0.2778
p.L62I	ACH-001061	Colon/Colorectal Cancer	CCLE	LEETPESS	DEG_SCF_FBW7_1	0.2778
p.L62I	HCT-15	large_intestine	COSMIC	LEETPESS	DEG_SCF_FBW7_1	0.2778
p.P81L	SIDM00007	Other Solid Cancers	GDSC	LEETPESS	DEG_SCF_FBW7_1	0.0556
p.P81L	MCC13	skin	COSMIC	LEETPESS	DEG_SCF_FBW7_1	0.0556
p.R80Q	SIDM00537	Colorectal Carcinoma	GDSC	LEETPESS	DEG_SCF_FBW7_1	0.0833
p.R80Q	ACH-000982	Colon/Colorectal Cancer	CCLE	LEETPESS	DEG_SCF_FBW7_1	0.0833
p.R80Q	ACH-001345	Colon/Colorectal Cancer	CCLE	LEETPESS	DEG_SCF_FBW7_1	0.0833
p.R80Q	GP5d	large_intestine	COSMIC	LEETPESS	DEG_SCF_FBW7_1	0.0833
p.E69Q	SIDM01322	Oral Cavity Carcinoma	GDSC	LEETPESS	DEG_SCF_FBW7_1	0.5633
p.E69Q	ACH-000735	Head and Neck Cancer	CCLE	LEETPESS	DEG_SCF_FBW7_1	0.5633
p.I74V	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	LEETPESS	DEG_SCF_FBW7_1	0.25
p.I74V	ACH-000813	Lung Cancer	CCLE	LEETPESS	DEG_SCF_FBW7_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LEETPESS

Degron related mutations and impact score

Drug responses associated with ASTL mutations

All proteins holding degron of LEETPESS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6HA08	Astacin-like metalloendopeptidase	DEG_SCF_FBW7_1	64:71	LEETPESS	FBXW7	0.7765	More...