DegronMD - Q6IA17(SIGIRR)

SIGIRR

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D355N	DO225346	BRCA	ICGC	RGPVFGE	LIG_APCC_ABBAyCdc20_2	359:365	Mutation rewiring degron network	0.2222
p.M358V	DO44489	KIRP	ICGC	RGPVFGE	LIG_APCC_ABBAyCdc20_2	359:365	Mutation rewiring degron network	0.3056
p.E374G	DO229268	THCA	ICGC	RGPVFGE	LIG_APCC_ABBAyCdc20_2	359:365	Mutation rewiring degron network	0.0833
p.G364R	SIDM00545	Melanoma	GDSC	RGPVFGE	LIG_APCC_ABBAyCdc20_2	359:365	Mutation altering degron motif	0.6457
p.G364R	ACH-000987	Skin Cancer	CCLE	RGPVFGE	LIG_APCC_ABBAyCdc20_2	359:365	Mutation altering degron motif	0.6457
p.G364R	Mewo	skin	COSMIC	RGPVFGE	LIG_APCC_ABBAyCdc20_2	359:365	Mutation altering degron motif	0.6457
p.H371N	SIDM00878	Breast Carcinoma	GDSC	RGPVFGE	LIG_APCC_ABBAyCdc20_2	359:365	Mutation rewiring degron network	0.1667
p.R359Q	SIDM00951	T-Lymphoblastic Leukemia	GDSC	RGPVFGE	LIG_APCC_ABBAyCdc20_2	359:365	Mutation altering degron motif	0.7329
p.R359Q	CTV-1	haematopoietic and lymphoid tissue	COSMIC	RGPVFGE	LIG_APCC_ABBAyCdc20_2	359:365	Mutation altering degron motif	0.7329
p.P369T	SIDM01660	Kidney Carcinoma	GDSC	RGPVFGE	LIG_APCC_ABBAyCdc20_2	359:365	Mutation rewiring degron network	0.2222
p.P369T	ACH-000709	Kidney Cancer	CCLE	RGPVFGE	LIG_APCC_ABBAyCdc20_2	359:365	Mutation rewiring degron network	0.2222
p.D351G	ACH-000937	Leukemia	CCLE	RGPVFGE	LIG_APCC_ABBAyCdc20_2	359:365	Mutation rewiring degron network	0.1111
p.P362S	IST-SL1	lung	COSMIC	RGPVFGE	LIG_APCC_ABBAyCdc20_2	359:365	Mutation altering degron motif	0.6752

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*NOTE: the Kaplan plots were collected from OncoLnc