DegronMD

Uniprot ID: Q6IA17

Source protein: Single Ig IL-1-related receptor

Source gene: SIGIRR

Class: LIG_APCC_ABBAyCdc20_2

Location: 359:365

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9886

ASA_SCORE: 77.0286

COIL: 0.8477

CONS_SCORE: 0.3213

DSS_SCORE: 0.7222

HELIX: 0.0164

FCONS_SCORE: 1.0077

RIG_SCORE: 0.6237

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D355N	DO225346	BRCA	ICGC	RGPVFGE	LIG_APCC_ABBAyCdc20_2	0.2222
p.M358V	DO44489	KIRP	ICGC	RGPVFGE	LIG_APCC_ABBAyCdc20_2	0.3056
p.E374G	DO229268	THCA	ICGC	RGPVFGE	LIG_APCC_ABBAyCdc20_2	0.0833
p.G364R	SIDM00545	Melanoma	GDSC	RGPVFGE	LIG_APCC_ABBAyCdc20_2	0.6457
p.G364R	ACH-000987	Skin Cancer	CCLE	RGPVFGE	LIG_APCC_ABBAyCdc20_2	0.6457
p.G364R	Mewo	skin	COSMIC	RGPVFGE	LIG_APCC_ABBAyCdc20_2	0.6457
p.H371N	SIDM00878	Breast Carcinoma	GDSC	RGPVFGE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R359Q	SIDM00951	T-Lymphoblastic Leukemia	GDSC	RGPVFGE	LIG_APCC_ABBAyCdc20_2	0.7329
p.R359Q	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	RGPVFGE	LIG_APCC_ABBAyCdc20_2	0.7329
p.P369T	SIDM01660	Kidney Carcinoma	GDSC	RGPVFGE	LIG_APCC_ABBAyCdc20_2	0.2222
p.P369T	ACH-000709	Kidney Cancer	CCLE	RGPVFGE	LIG_APCC_ABBAyCdc20_2	0.2222
p.D351G	ACH-000937	Leukemia	CCLE	RGPVFGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.P362S	IST-SL1	lung	COSMIC	RGPVFGE	LIG_APCC_ABBAyCdc20_2	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6IA17	Single Ig IL-1-related receptor	LIG_APCC_ABBAyCdc20_2	359:365	RGPVFGE	APC,CDC20,FZR1	0.9886	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons