DegronMD - Q6IB77(GLYAT)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T73S	TCGA-55-6975	LUAD	TCGA	NTYQIYSKDP	CBL_PTK	74:83	Mutation rewiring degron network	0.3056
p.T73S	DO23684	LUAD	ICGC	NTYQIYSKDP	CBL_PTK	74:83	Mutation rewiring degron network	0.3056
p.T73S	SIDM00814	Other Solid Cancers	GDSC	NTYQIYSKDP	CBL_PTK	74:83	Mutation rewiring degron network	0.3056
p.T73S	ACH-001401	Adrenal Cancer	CCLE	NTYQIYSKDP	CBL_PTK	74:83	Mutation rewiring degron network	0.3056
p.T73S	SW13	adrenal gland	COSMIC	NTYQIYSKDP	CBL_PTK	74:83	Mutation rewiring degron network	0.3056
p.I78M	TCGA-BB-A5HY	HNSC	TCGA	NTYQIYSKDP	CBL_PTK	74:83	Mutation altering degron motif	0.6507
p.I78M	DO218979	HNSC	ICGC	NTYQIYSKDP	CBL_PTK	74:83	Mutation altering degron motif	0.6507
p.L90P	TCGA-CD-5801	STAD	TCGA	NTYQIYSKDP	CBL_PTK	74:83	Mutation rewiring degron network	0.1389
p.L90P	DO38563	STAD	ICGC	NTYQIYSKDP	CBL_PTK	74:83	Mutation rewiring degron network	0.1389
p.T75I	TCGA-CN-5369	HNSC	TCGA	NTYQIYSKDP	CBL_PTK	74:83	Mutation altering degron motif	0.5966
p.T75I	DO16069	HNSC	ICGC	NTYQIYSKDP	CBL_PTK	74:83	Mutation altering degron motif	0.5966
p.P83L	TCGA-D3-A51G	SKCM	TCGA	NTYQIYSKDP	CBL_PTK	74:83	Mutation altering degron motif	0.7582
p.P83L	DO220886	MELA	ICGC	NTYQIYSKDP	CBL_PTK	74:83	Mutation altering degron motif	0.7582
p.P83L	DO229465	SKCA	ICGC	NTYQIYSKDP	CBL_PTK	74:83	Mutation altering degron motif	0.7582
p.P83L	DO47700	SKCM	ICGC	NTYQIYSKDP	CBL_PTK	74:83	Mutation altering degron motif	0.7582
p.S92L	TCGA-D3-A8GL	SKCM	TCGA	NTYQIYSKDP	CBL_PTK	74:83	Mutation rewiring degron network	0.0833
p.S92L	DO220906	MELA	ICGC	NTYQIYSKDP	CBL_PTK	74:83	Mutation rewiring degron network	0.0833
p.S92L	DO50287	SKCM	ICGC	NTYQIYSKDP	CBL_PTK	74:83	Mutation rewiring degron network	0.0833
p.P93Q	TCGA-DA-A1IB	SKCM	TCGA	NTYQIYSKDP	CBL_PTK	74:83	Mutation rewiring degron network	0.0556
p.P93Q	DO38033	SKCM	ICGC	NTYQIYSKDP	CBL_PTK	74:83	Mutation rewiring degron network	0.0556
p.S80F	TCGA-EO-A22U	UCEC	TCGA	NTYQIYSKDP	CBL_PTK	74:83	Mutation altering degron motif	0.7982
p.S80F	DO43755	UCEC	ICGC	NTYQIYSKDP	CBL_PTK	74:83	Mutation altering degron motif	0.7982
p.L90F	TCGA-QC-A7B5	SARC	TCGA	NTYQIYSKDP	CBL_PTK	74:83	Mutation rewiring degron network	0.1389
p.L90F	DO220239	SARC	ICGC	NTYQIYSKDP	CBL_PTK	74:83	Mutation rewiring degron network	0.1389
p.G91V	DO233206	GACA	ICGC	NTYQIYSKDP	CBL_PTK	74:83	Mutation rewiring degron network	0.1111
p.D82N	DO220877	MELA	ICGC	NTYQIYSKDP	CBL_PTK	74:83	Mutation altering degron motif	0.5821
p.V66A	DO222843	MELA	ICGC	NTYQIYSKDP	CBL_PTK	74:83	Mutation rewiring degron network	0.1111
p.T73I	SIDM00075	Non-Cancerous	GDSC	NTYQIYSKDP	CBL_PTK	74:83	Mutation rewiring degron network	0.3056
p.T73I	SIDM00544	Neuroblastoma	GDSC	NTYQIYSKDP	CBL_PTK	74:83	Mutation rewiring degron network	0.3056
p.T73I	SIDM00555	Glioblastoma	GDSC	NTYQIYSKDP	CBL_PTK	74:83	Mutation rewiring degron network	0.3056
p.T73I	SIDM00463	T-Lymphoblastic Leukemia	GDSC	NTYQIYSKDP	CBL_PTK	74:83	Mutation rewiring degron network	0.3056
p.T73I	SIDM01259	B-Lymphoblastic Leukemia	GDSC	NTYQIYSKDP	CBL_PTK	74:83	Mutation rewiring degron network	0.3056
p.T73I	SIDM00562	Breast Carcinoma	GDSC	NTYQIYSKDP	CBL_PTK	74:83	Mutation rewiring degron network	0.3056
p.T73I	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	NTYQIYSKDP	CBL_PTK	74:83	Mutation rewiring degron network	0.3056
p.T73I	SIDM01146	Gastric Carcinoma	GDSC	NTYQIYSKDP	CBL_PTK	74:83	Mutation rewiring degron network	0.3056
p.T73I	SIDM00365	Small Cell Lung Carcinoma	GDSC	NTYQIYSKDP	CBL_PTK	74:83	Mutation rewiring degron network	0.3056
p.T73I	SIDM00543	Melanoma	GDSC	NTYQIYSKDP	CBL_PTK	74:83	Mutation rewiring degron network	0.3056
p.T73I	SIDM00363	Acute Myeloid Leukemia	GDSC	NTYQIYSKDP	CBL_PTK	74:83	Mutation rewiring degron network	0.3056
p.T73I	SIDM01018	Hodgkin's Lymphoma	GDSC	NTYQIYSKDP	CBL_PTK	74:83	Mutation rewiring degron network	0.3056
p.T73I	SIDM01727	Chronic Myelogenous Leukemia	GDSC	NTYQIYSKDP	CBL_PTK	74:83	Mutation rewiring degron network	0.3056
p.T73I	SIDM00164	Biliary Tract Carcinoma	GDSC	NTYQIYSKDP	CBL_PTK	74:83	Mutation rewiring degron network	0.3056
p.T73I	SIDM01618	B-Lymphoblastic Leukemia	GDSC	NTYQIYSKDP	CBL_PTK	74:83	Mutation rewiring degron network	0.3056
p.K81E	SIDM00426	Rhabdomyosarcoma	GDSC	NTYQIYSKDP	CBL_PTK	74:83	Mutation altering degron motif	0.591
p.K81E	ACH-000100	Sarcoma	CCLE	NTYQIYSKDP	CBL_PTK	74:83	Mutation altering degron motif	0.591
p.K81E	ACH-001765	Sarcoma	CCLE	NTYQIYSKDP	CBL_PTK	74:83	Mutation altering degron motif	0.591
p.K81E	RH-41	soft tissue	COSMIC	NTYQIYSKDP	CBL_PTK	74:83	Mutation altering degron motif	0.591

Kaplan plot for GLYAT in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GLYAT

UniProt ID: Q6IB77

Entrez ID: 10249

Protein name: Glycine N-acyltransferase (EC 2.3.1.13) (Acyl-CoA:glycine N-acyltransferase) (AAc) (Aralkyl acyl-CoA N-acyltransferase) (Aralkyl acyl-CoA:amino acid N-acyltransferase) (Benzoyl-coenzyme A:glycine N-acyltransferase) (Glycine N-benzoyltransferase) (EC 2.3.1.71) (HRP-1(CLP))

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GLYAT in