DegronMD

Uniprot ID: Q6IB77

Source protein: Glycine N-acyltransferase

Source gene: GLYAT

Class: CBL_PTK

Location: 74:83

E3 ligase: CBL

DEGRON score: 0.5444

ASA_SCORE: 49.67

COIL: 0.5911

CONS_SCORE: 0.564

DSS_SCORE: 0.3907

HELIX: 0.2324

FCONS_SCORE: 0.9908

RIG_SCORE: 0.8247

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T73S	TCGA-55-6975	LUAD	TCGA	NTYQIYSKDP	CBL_PTK	0.3056
p.T73S	DO23684	LUAD	ICGC	NTYQIYSKDP	CBL_PTK	0.3056
p.T73S	SIDM00814	Other Solid Cancers	GDSC	NTYQIYSKDP	CBL_PTK	0.3056
p.T73S	ACH-001401	Adrenal Cancer	CCLE	NTYQIYSKDP	CBL_PTK	0.3056
p.T73S	SW13	adrenal_gland	COSMIC	NTYQIYSKDP	CBL_PTK	0.3056
p.I78M	TCGA-BB-A5HY	HNSC	TCGA	NTYQIYSKDP	CBL_PTK	0.6507
p.I78M	DO218979	HNSC	ICGC	NTYQIYSKDP	CBL_PTK	0.6507
p.L90P	TCGA-CD-5801	STAD	TCGA	NTYQIYSKDP	CBL_PTK	0.1389
p.L90P	DO38563	STAD	ICGC	NTYQIYSKDP	CBL_PTK	0.1389
p.T75I	TCGA-CN-5369	HNSC	TCGA	NTYQIYSKDP	CBL_PTK	0.5966
p.T75I	DO16069	HNSC	ICGC	NTYQIYSKDP	CBL_PTK	0.5966
p.P83L	TCGA-D3-A51G	SKCM	TCGA	NTYQIYSKDP	CBL_PTK	0.7582
p.P83L	DO220886	MELA	ICGC	NTYQIYSKDP	CBL_PTK	0.7582
p.P83L	DO229465	SKCA	ICGC	NTYQIYSKDP	CBL_PTK	0.7582
p.P83L	DO47700	SKCM	ICGC	NTYQIYSKDP	CBL_PTK	0.7582
p.S92L	TCGA-D3-A8GL	SKCM	TCGA	NTYQIYSKDP	CBL_PTK	0.0833
p.S92L	DO220906	MELA	ICGC	NTYQIYSKDP	CBL_PTK	0.0833
p.S92L	DO50287	SKCM	ICGC	NTYQIYSKDP	CBL_PTK	0.0833
p.P93Q	TCGA-DA-A1IB	SKCM	TCGA	NTYQIYSKDP	CBL_PTK	0.0556
p.P93Q	DO38033	SKCM	ICGC	NTYQIYSKDP	CBL_PTK	0.0556
p.S80F	TCGA-EO-A22U	UCEC	TCGA	NTYQIYSKDP	CBL_PTK	0.7982
p.S80F	DO43755	UCEC	ICGC	NTYQIYSKDP	CBL_PTK	0.7982
p.L90F	TCGA-QC-A7B5	SARC	TCGA	NTYQIYSKDP	CBL_PTK	0.1389
p.L90F	DO220239	SARC	ICGC	NTYQIYSKDP	CBL_PTK	0.1389
p.G91V	DO233206	GACA	ICGC	NTYQIYSKDP	CBL_PTK	0.1111
p.D82N	DO220877	MELA	ICGC	NTYQIYSKDP	CBL_PTK	0.5821
p.V66A	DO222843	MELA	ICGC	NTYQIYSKDP	CBL_PTK	0.1111
p.T73I	SIDM00075	Non-Cancerous	GDSC	NTYQIYSKDP	CBL_PTK	0.3056
p.T73I	SIDM00544	Neuroblastoma	GDSC	NTYQIYSKDP	CBL_PTK	0.3056
p.T73I	SIDM00555	Glioblastoma	GDSC	NTYQIYSKDP	CBL_PTK	0.3056
p.T73I	SIDM00463	T-Lymphoblastic Leukemia	GDSC	NTYQIYSKDP	CBL_PTK	0.3056
p.T73I	SIDM01259	B-Lymphoblastic Leukemia	GDSC	NTYQIYSKDP	CBL_PTK	0.3056
p.T73I	SIDM00562	Breast Carcinoma	GDSC	NTYQIYSKDP	CBL_PTK	0.3056
p.T73I	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	NTYQIYSKDP	CBL_PTK	0.3056
p.T73I	SIDM01146	Gastric Carcinoma	GDSC	NTYQIYSKDP	CBL_PTK	0.3056
p.T73I	SIDM00365	Small Cell Lung Carcinoma	GDSC	NTYQIYSKDP	CBL_PTK	0.3056
p.T73I	SIDM00543	Melanoma	GDSC	NTYQIYSKDP	CBL_PTK	0.3056
p.T73I	SIDM00363	Acute Myeloid Leukemia	GDSC	NTYQIYSKDP	CBL_PTK	0.3056
p.T73I	SIDM01018	Hodgkin's Lymphoma	GDSC	NTYQIYSKDP	CBL_PTK	0.3056
p.T73I	SIDM01727	Chronic Myelogenous Leukemia	GDSC	NTYQIYSKDP	CBL_PTK	0.3056
p.T73I	SIDM00164	Biliary Tract Carcinoma	GDSC	NTYQIYSKDP	CBL_PTK	0.3056
p.T73I	SIDM01618	B-Lymphoblastic Leukemia	GDSC	NTYQIYSKDP	CBL_PTK	0.3056
p.K81E	SIDM00426	Rhabdomyosarcoma	GDSC	NTYQIYSKDP	CBL_PTK	0.591
p.K81E	ACH-000100	Sarcoma	CCLE	NTYQIYSKDP	CBL_PTK	0.591
p.K81E	ACH-001765	Sarcoma	CCLE	NTYQIYSKDP	CBL_PTK	0.591
p.K81E	RH-41	soft_tissue	COSMIC	NTYQIYSKDP	CBL_PTK	0.591

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NTYQIYSKDP

Degron related mutations and impact score

Drug responses associated with GLYAT mutations

All proteins holding degron of NTYQIYSKDP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6IB77	Glycine N-acyltransferase	CBL_PTK	74:83	NTYQIYSKDP	CBL	0.5444	More...