DegronMD - Q6ICH7(ASPHD2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A183T	TCGA-12-1092	GBM	TCGA	LPTTPYFS	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.25
p.A183T	DO222809	COCA	ICGC	LPTTPYFS	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.25
p.A183T	DO11992	GBM	ICGC	LPTTPYFS	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.25
p.A183T	SIDM00498	Colorectal Carcinoma	GDSC	LPTTPYFS	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.25
p.A183T	SIDM00534	Colorectal Carcinoma	GDSC	LPTTPYFS	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.25
p.A183T	ACH-000970	Colon/Colorectal Cancer	CCLE	LPTTPYFS	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.25
p.A183T	ACH-000986	Colon/Colorectal Cancer	CCLE	LPTTPYFS	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.25
p.A183T	HT-115	large intestine	COSMIC	LPTTPYFS	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.25
p.A183T	SNU-C5	large intestine	COSMIC	LPTTPYFS	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.25
p.P174L	TCGA-4Z-AA86	BLCA	TCGA	LPTTPYFS	DEG_SCF_FBW7_1	173:180	Mutation altering degron motif	0.6471
p.P174L	DO218989	BLCA	ICGC	LPTTPYFS	DEG_SCF_FBW7_1	173:180	Mutation altering degron motif	0.6471
p.P171S	TCGA-AP-A1DK	UCEC	TCGA	LPTTPYFS	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.2778
p.P171S	DO42033	UCEC	ICGC	LPTTPYFS	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.2778
p.D172N	TCGA-E6-A2P8	UCEC	TCGA	LPTTPYFS	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.3056
p.D172N	DO40924	UCEC	ICGC	LPTTPYFS	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.3056
p.P174A	TCGA-EI-6514	READ	TCGA	LPTTPYFS	DEG_SCF_FBW7_1	173:180	Mutation altering degron motif	0.6392
p.P174A	DO36427	READ	ICGC	LPTTPYFS	DEG_SCF_FBW7_1	173:180	Mutation altering degron motif	0.6392
p.T176M	TCGA-EY-A1H0	UCEC	TCGA	LPTTPYFS	DEG_SCF_FBW7_1	173:180	Mutation altering degron motif	0.7423
p.T176M	DO43114	UCEC	ICGC	LPTTPYFS	DEG_SCF_FBW7_1	173:180	Mutation altering degron motif	0.7423
p.R181W	DO222810	MELA	ICGC	LPTTPYFS	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.3056
p.P174S	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	LPTTPYFS	DEG_SCF_FBW7_1	173:180	Mutation altering degron motif	0.5641
p.P174S	ACH-001638	Lymphoma	CCLE	LPTTPYFS	DEG_SCF_FBW7_1	173:180	Mutation altering degron motif	0.5641
p.P174S	RC-K8	haematopoietic and lymphoid tissue	COSMIC	LPTTPYFS	DEG_SCF_FBW7_1	173:180	Mutation altering degron motif	0.5641
p.Q163R	SIDM00451	T-Lymphoblastic Leukemia	GDSC	LPTTPYFS	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.0556
p.Q163R	ACH-000937	Leukemia	CCLE	LPTTPYFS	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.0556
p.Q163R	PF-382	haematopoietic and lymphoid tissue	COSMIC	LPTTPYFS	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.0556
p.T175N	ACH-000109	Lung Cancer	CCLE	LPTTPYFS	DEG_SCF_FBW7_1	173:180	Mutation altering degron motif	0.5944

Kaplan plot for ASPHD2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ASPHD2

UniProt ID: Q6ICH7

Entrez ID: 57168

Protein name: Aspartate beta-hydroxylase domain-containing protein 2 (EC 1.14.11.-)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ASPHD2 in