DegronMD

Uniprot ID: Q6ICH7

Source protein: Aspartate beta-hydroxylase domain-containing protein 2

Source gene: ASPHD2

Class: DEG_SCF_FBW7_1

Location: 173:180

E3 ligase: FBXW7

DEGRON score: 0.7787

ASA_SCORE: 48.025

COIL: 0.9201

CONS_SCORE: 0.5042

DSS_SCORE: 0.3418

HELIX: 0.0174

FCONS_SCORE: 1.0546

RIG_SCORE: 0.762

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A183T	TCGA-12-1092	GBM	TCGA	LPTTPYFS	DEG_SCF_FBW7_1	0.25
p.A183T	DO222809	COCA	ICGC	LPTTPYFS	DEG_SCF_FBW7_1	0.25
p.A183T	DO11992	GBM	ICGC	LPTTPYFS	DEG_SCF_FBW7_1	0.25
p.A183T	SIDM00498	Colorectal Carcinoma	GDSC	LPTTPYFS	DEG_SCF_FBW7_1	0.25
p.A183T	SIDM00534	Colorectal Carcinoma	GDSC	LPTTPYFS	DEG_SCF_FBW7_1	0.25
p.A183T	ACH-000970	Colon/Colorectal Cancer	CCLE	LPTTPYFS	DEG_SCF_FBW7_1	0.25
p.A183T	ACH-000986	Colon/Colorectal Cancer	CCLE	LPTTPYFS	DEG_SCF_FBW7_1	0.25
p.A183T	HT-115	large_intestine	COSMIC	LPTTPYFS	DEG_SCF_FBW7_1	0.25
p.A183T	SNU-C5	large_intestine	COSMIC	LPTTPYFS	DEG_SCF_FBW7_1	0.25
p.P174L	TCGA-4Z-AA86	BLCA	TCGA	LPTTPYFS	DEG_SCF_FBW7_1	0.6471
p.P174L	DO218989	BLCA	ICGC	LPTTPYFS	DEG_SCF_FBW7_1	0.6471
p.P171S	TCGA-AP-A1DK	UCEC	TCGA	LPTTPYFS	DEG_SCF_FBW7_1	0.2778
p.P171S	DO42033	UCEC	ICGC	LPTTPYFS	DEG_SCF_FBW7_1	0.2778
p.D172N	TCGA-E6-A2P8	UCEC	TCGA	LPTTPYFS	DEG_SCF_FBW7_1	0.3056
p.D172N	DO40924	UCEC	ICGC	LPTTPYFS	DEG_SCF_FBW7_1	0.3056
p.P174A	TCGA-EI-6514	READ	TCGA	LPTTPYFS	DEG_SCF_FBW7_1	0.6392
p.P174A	DO36427	READ	ICGC	LPTTPYFS	DEG_SCF_FBW7_1	0.6392
p.T176M	TCGA-EY-A1H0	UCEC	TCGA	LPTTPYFS	DEG_SCF_FBW7_1	0.7423
p.T176M	DO43114	UCEC	ICGC	LPTTPYFS	DEG_SCF_FBW7_1	0.7423
p.R181W	DO222810	MELA	ICGC	LPTTPYFS	DEG_SCF_FBW7_1	0.3056
p.P174S	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	LPTTPYFS	DEG_SCF_FBW7_1	0.5641
p.P174S	ACH-001638	Lymphoma	CCLE	LPTTPYFS	DEG_SCF_FBW7_1	0.5641
p.P174S	RC-K8	haematopoietic_and_lymphoid_tissue	COSMIC	LPTTPYFS	DEG_SCF_FBW7_1	0.5641
p.Q163R	SIDM00451	T-Lymphoblastic Leukemia	GDSC	LPTTPYFS	DEG_SCF_FBW7_1	0.0556
p.Q163R	ACH-000937	Leukemia	CCLE	LPTTPYFS	DEG_SCF_FBW7_1	0.0556
p.Q163R	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	LPTTPYFS	DEG_SCF_FBW7_1	0.0556
p.T175N	ACH-000109	Lung Cancer	CCLE	LPTTPYFS	DEG_SCF_FBW7_1	0.5944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LPTTPYFS

Degron related mutations and impact score

Drug responses associated with ASPHD2 mutations

All proteins holding degron of LPTTPYFS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ICH7	Aspartate beta-hydroxylase domain-containing protein 2	DEG_SCF_FBW7_1	173:180	LPTTPYFS	FBXW7	0.7787	More...