DegronMD - Q6IQ23(PLEKHA7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P936L	TCGA-AP-A1DK	UCEC	TCGA	PRPPLPELY	DEG_APCC_DBOX_1	921:929	Mutation rewiring degron network	0.1389
p.E916K	TCGA-EE-A29D	SKCM	TCGA	PRPPLPELY	DEG_APCC_DBOX_1	921:929	Mutation rewiring degron network	0.1944
p.E916K	TCGA-EE-A2GI	SKCM	TCGA	PRPPLPELY	DEG_APCC_DBOX_1	921:929	Mutation rewiring degron network	0.1944
p.E927K	TCGA-EO-A22U	UCEC	TCGA	PRPPLPELY	DEG_APCC_DBOX_1	921:929	Mutation altering degron motif	0.591
p.E927K	SIDM01750	Melanoma	GDSC	PRPPLPELY	DEG_APCC_DBOX_1	921:929	Mutation altering degron motif	0.591
p.E927K	ACH-000801	Skin Cancer	CCLE	PRPPLPELY	DEG_APCC_DBOX_1	921:929	Mutation altering degron motif	0.591
p.P939L	TCGA-MX-A5UJ	STAD	TCGA	PRPPLPELY	DEG_APCC_DBOX_1	921:929	Mutation rewiring degron network	0.0556
p.P939L	SIDM01617	Endometrial Carcinoma	GDSC	PRPPLPELY	DEG_APCC_DBOX_1	921:929	Mutation rewiring degron network	0.0556
p.P939L	ACH-000994	Endometrial/Uterine Cancer	CCLE	PRPPLPELY	DEG_APCC_DBOX_1	921:929	Mutation rewiring degron network	0.0556
p.P932L	DO229325	BTCA	ICGC	PRPPLPELY	DEG_APCC_DBOX_1	921:929	Mutation rewiring degron network	0.25
p.L929I	DO229024	LICA	ICGC	PRPPLPELY	DEG_APCC_DBOX_1	921:929	Mutation altering degron motif	0.7174
p.P937S	DO222536	MELA	ICGC	PRPPLPELY	DEG_APCC_DBOX_1	921:929	Mutation rewiring degron network	0.1111
p.E917K	DO37410	SKCM	ICGC	PRPPLPELY	DEG_APCC_DBOX_1	921:929	Mutation rewiring degron network	0.2222
p.E917K	DO38123	SKCM	ICGC	PRPPLPELY	DEG_APCC_DBOX_1	921:929	Mutation rewiring degron network	0.2222
p.P937L	DO42033	UCEC	ICGC	PRPPLPELY	DEG_APCC_DBOX_1	921:929	Mutation rewiring degron network	0.1111
p.E928K	DO43755	UCEC	ICGC	PRPPLPELY	DEG_APCC_DBOX_1	921:929	Mutation altering degron motif	0.7022
p.A911V	ACH-000937	Leukemia	CCLE	PRPPLPELY	DEG_APCC_DBOX_1	921:929	Mutation rewiring degron network	0.0556
p.A911V	PF-382	haematopoietic and lymphoid tissue	COSMIC	PRPPLPELY	DEG_APCC_DBOX_1	921:929	Mutation rewiring degron network	0.0556
p.Q934K	ACH-000939	Sarcoma	CCLE	PRPPLPELY	DEG_APCC_DBOX_1	921:929	Mutation rewiring degron network	0.1944

Kaplan plot for PLEKHA7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLEKHA7

UniProt ID: Q6IQ23

Entrez ID: 144100

Protein name: Pleckstrin homology domain-containing family A member 7 (PH domain-containing family A member 7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLEKHA7 in