DegronMD

Uniprot ID: Q6IQ23

Source protein: Pleckstrin homology domain-containing family A member 7

Source gene: PLEKHA7

Class: DEG_APCC_DBOX_1

Location: 921:929

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9976

ASA_SCORE: 98.4111

COIL: 0.9363

CONS_SCORE: 0.6588

DSS_SCORE: 0.7674

HELIX: 0.0409

FCONS_SCORE: 1.3295

RIG_SCORE: 0.585

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P936L	TCGA-AP-A1DK	UCEC	TCGA	PRPPLPELY	DEG_APCC_DBOX_1	0.1389
p.E916K	TCGA-EE-A29D	SKCM	TCGA	PRPPLPELY	DEG_APCC_DBOX_1	0.1944
p.E916K	TCGA-EE-A2GI	SKCM	TCGA	PRPPLPELY	DEG_APCC_DBOX_1	0.1944
p.E927K	TCGA-EO-A22U	UCEC	TCGA	PRPPLPELY	DEG_APCC_DBOX_1	0.591
p.E927K	SIDM01750	Melanoma	GDSC	PRPPLPELY	DEG_APCC_DBOX_1	0.591
p.E927K	ACH-000801	Skin Cancer	CCLE	PRPPLPELY	DEG_APCC_DBOX_1	0.591
p.P939L	TCGA-MX-A5UJ	STAD	TCGA	PRPPLPELY	DEG_APCC_DBOX_1	0.0556
p.P939L	SIDM01617	Endometrial Carcinoma	GDSC	PRPPLPELY	DEG_APCC_DBOX_1	0.0556
p.P939L	ACH-000994	Endometrial/Uterine Cancer	CCLE	PRPPLPELY	DEG_APCC_DBOX_1	0.0556
p.P932L	DO229325	BTCA	ICGC	PRPPLPELY	DEG_APCC_DBOX_1	0.25
p.L929I	DO229024	LICA	ICGC	PRPPLPELY	DEG_APCC_DBOX_1	0.7174
p.P937S	DO222536	MELA	ICGC	PRPPLPELY	DEG_APCC_DBOX_1	0.1111
p.E917K	DO37410	SKCM	ICGC	PRPPLPELY	DEG_APCC_DBOX_1	0.2222
p.E917K	DO38123	SKCM	ICGC	PRPPLPELY	DEG_APCC_DBOX_1	0.2222
p.P937L	DO42033	UCEC	ICGC	PRPPLPELY	DEG_APCC_DBOX_1	0.1111
p.E928K	DO43755	UCEC	ICGC	PRPPLPELY	DEG_APCC_DBOX_1	0.7022
p.A911V	ACH-000937	Leukemia	CCLE	PRPPLPELY	DEG_APCC_DBOX_1	0.0556
p.A911V	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	PRPPLPELY	DEG_APCC_DBOX_1	0.0556
p.Q934K	ACH-000939	Sarcoma	CCLE	PRPPLPELY	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6IQ23	Pleckstrin homology domain-containing family A member 7	DEG_APCC_DBOX_1	921:929	PRPPLPELY	APC,CDC20,FZR1	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons