DegronMD - Q6IQ26(DENND5A)

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R471Q	TCGA-E9-A295	BRCA	TCGA	LKENE	DEG_APCC_KENBOX_2	463:467	Mutation rewiring degron network	0.2222
p.R471Q	DO3703	BRCA	ICGC	LKENE	DEG_APCC_KENBOX_2	463:467	Mutation rewiring degron network	0.2222
p.R471Q	ACH-001673	Bile Duct Cancer	CCLE	LKENE	DEG_APCC_KENBOX_2	463:467	Mutation rewiring degron network	0.2222
p.L463P	DO233671	GACA	ICGC	LKENE	DEG_APCC_KENBOX_2	463:467	Mutation altering degron motif	0.6471
p.H467N	DO229019	LICA	ICGC	LKENE	DEG_APCC_KENBOX_2	463:467	Mutation altering degron motif	0.7423
p.R473L	DO47407	SKCM	ICGC	LKENE	DEG_APCC_KENBOX_2	463:467	Mutation rewiring degron network	0.1667
p.F466L	DO41020	UCEC	ICGC	LKENE	DEG_APCC_KENBOX_2	463:467	Mutation altering degron motif	0.6981
p.K477E	SIDM00907	Burkitt's Lymphoma	GDSC	LKENE	DEG_APCC_KENBOX_2	463:467	Mutation blocking ubiquitination signal	0.5
p.K477E	SIDM01257	Hepatocellular Carcinoma	GDSC	LKENE	DEG_APCC_KENBOX_2	463:467	Mutation blocking ubiquitination signal	0.5
p.K477E	SIDM00062	Hepatocellular Carcinoma	GDSC	LKENE	DEG_APCC_KENBOX_2	463:467	Mutation blocking ubiquitination signal	0.5

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons