DegronMD

Uniprot ID: Q6IQ26

Source protein: DENN domain-containing protein 5A

Source gene: DENND5A

Class: DEG_APCC_KENBOX_2

Location: 463:467

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7918

ASA_SCORE: 86.98

COIL: 0.5298

CONS_SCORE: 0.2916

DSS_SCORE: 0.2615

HELIX: 0.4606

FCONS_SCORE: 0.9876

RIG_SCORE: 0.7954

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R471Q	TCGA-E9-A295	BRCA	TCGA	LKENE	DEG_APCC_KENBOX_2	0.2222
p.R471Q	DO3703	BRCA	ICGC	LKENE	DEG_APCC_KENBOX_2	0.2222
p.R471Q	ACH-001673	Bile Duct Cancer	CCLE	LKENE	DEG_APCC_KENBOX_2	0.2222
p.L463P	DO233671	GACA	ICGC	LKENE	DEG_APCC_KENBOX_2	0.6471
p.H467N	DO229019	LICA	ICGC	LKENE	DEG_APCC_KENBOX_2	0.7423
p.R473L	DO47407	SKCM	ICGC	LKENE	DEG_APCC_KENBOX_2	0.1667
p.F466L	DO41020	UCEC	ICGC	LKENE	DEG_APCC_KENBOX_2	0.6981
p.K477E	SIDM00907	Burkitt's Lymphoma	GDSC	LKENE	DEG_APCC_KENBOX_2	0.5
p.K477E	SIDM01257	Hepatocellular Carcinoma	GDSC	LKENE	DEG_APCC_KENBOX_2	0.5
p.K477E	SIDM00062	Hepatocellular Carcinoma	GDSC	LKENE	DEG_APCC_KENBOX_2	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6IQ26	DENN domain-containing protein 5A	DEG_APCC_KENBOX_2	463:467	LKENE	APC,CDC20,FZR1	0.7918	More...
Q6P4F7	Rho GTPase-activating protein 11A	DEG_APCC_KENBOX_2	737:741	LKENE	APC,CDC20,FZR1	0.8239	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons