DegronMD - Q6P4F7(ARHGAP11A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R839C	TCGA-06-5416	GBM	TCGA	NSLLEYSRQP	CBL_PTK	846:855	Mutation rewiring degron network	0.1389
p.R839C	DO10880	GBM	ICGC	NSLLEYSRQP	CBL_PTK	846:855	Mutation rewiring degron network	0.1389
p.R839C	SIDM00118	Colorectal Carcinoma	GDSC	NSLLEYSRQP	CBL_PTK	846:855	Mutation rewiring degron network	0.1389
p.R839C	SIDM01588	Endometrial Carcinoma	GDSC	NSLLEYSRQP	CBL_PTK	846:855	Mutation rewiring degron network	0.1389
p.R839C	HCC2998	large intestine	COSMIC	NSLLEYSRQP	CBL_PTK	846:855	Mutation rewiring degron network	0.1389
p.N747K	TCGA-86-7713	LUAD	TCGA	LKENE	DEG_APCC_KENBOX_2	737:741	Mutation rewiring degron network	0.1667
p.N747K	DO24712	LUAD	ICGC	LKENE	DEG_APCC_KENBOX_2	737:741	Mutation rewiring degron network	0.1667
p.G857R	TCGA-96-A4JK	LUSC	TCGA	NSLLEYSRQP	CBL_PTK	846:855	Mutation rewiring degron network	0.2778
p.G857R	TCGA-UF-A71D	HNSC	TCGA	NSLLEYSRQP	CBL_PTK	846:855	Mutation rewiring degron network	0.2778
p.G857R	DO52109	HNSC	ICGC	NSLLEYSRQP	CBL_PTK	846:855	Mutation rewiring degron network	0.2778
p.G857R	DO45442	LUSC	ICGC	NSLLEYSRQP	CBL_PTK	846:855	Mutation rewiring degron network	0.2778
p.D372N	TCGA-A5-A2K3	UCEC	TCGA	VSVHID	LIG_APCC_ABBA_1	367:372	Mutation altering degron motif	0.6932
p.D372N	TCGA-ER-A42L	SKCM	TCGA	VSVHID	LIG_APCC_ABBA_1	367:372	Mutation altering degron motif	0.6932
p.D372N	DO223910	SKCM	ICGC	VSVHID	LIG_APCC_ABBA_1	367:372	Mutation altering degron motif	0.6932
p.D372N	DO43899	UCEC	ICGC	VSVHID	LIG_APCC_ABBA_1	367:372	Mutation altering degron motif	0.6932
p.A313P	TCGA-AA-A01X	COAD	TCGA	PNRTPSIT	DEG_SCF_FBW7_1	299:306	Mutation rewiring degron network	0.1389
p.A313P	TCGA-AA-A01X	COAD	TCGA	PSITPQEE	DEG_SCF_FBW7_2	303:310	Mutation rewiring degron network	0.25
p.A313P	DO8004	COAD	ICGC	PNRTPSIT	DEG_SCF_FBW7_1	299:306	Mutation rewiring degron network	0.1389
p.A313P	DO8004	COAD	ICGC	PSITPQEE	DEG_SCF_FBW7_2	303:310	Mutation rewiring degron network	0.25
p.L258I	TCGA-AG-A002	READ	TCGA	LCATPSLE	DEG_SCF_FBW7_2	258:265	Mutation altering degron motif	0.6063
p.R311I	TCGA-AP-A056	UCEC	TCGA	PNRTPSIT	DEG_SCF_FBW7_1	299:306	Mutation rewiring degron network	0.1944
p.R311I	TCGA-AP-A056	UCEC	TCGA	PSITPQEE	DEG_SCF_FBW7_2	303:310	Mutation rewiring degron network	0.3056
p.R311I	TCGA-AX-A0J0	UCEC	TCGA	PNRTPSIT	DEG_SCF_FBW7_1	299:306	Mutation rewiring degron network	0.1944
p.R311I	TCGA-AX-A0J0	UCEC	TCGA	PSITPQEE	DEG_SCF_FBW7_2	303:310	Mutation rewiring degron network	0.3056
p.R311I	TCGA-EO-A3AY	UCEC	TCGA	PNRTPSIT	DEG_SCF_FBW7_1	299:306	Mutation rewiring degron network	0.1944
p.R311I	TCGA-EO-A3AY	UCEC	TCGA	PSITPQEE	DEG_SCF_FBW7_2	303:310	Mutation rewiring degron network	0.3056
p.R311I	DO43202	UCEC	ICGC	PNRTPSIT	DEG_SCF_FBW7_1	299:306	Mutation rewiring degron network	0.1944
p.R311I	DO43202	UCEC	ICGC	PSITPQEE	DEG_SCF_FBW7_2	303:310	Mutation rewiring degron network	0.3056
p.R311I	DO41133	UCEC	ICGC	PNRTPSIT	DEG_SCF_FBW7_1	299:306	Mutation rewiring degron network	0.1944
p.R311I	DO41133	UCEC	ICGC	PSITPQEE	DEG_SCF_FBW7_2	303:310	Mutation rewiring degron network	0.3056
p.R311I	DO43971	UCEC	ICGC	PNRTPSIT	DEG_SCF_FBW7_1	299:306	Mutation rewiring degron network	0.1944
p.R311I	DO43971	UCEC	ICGC	PSITPQEE	DEG_SCF_FBW7_2	303:310	Mutation rewiring degron network	0.3056
p.R311I	SIDM01588	Endometrial Carcinoma	GDSC	PNRTPSIT	DEG_SCF_FBW7_1	299:306	Mutation rewiring degron network	0.1944
p.R311I	SIDM01588	Endometrial Carcinoma	GDSC	PSITPQEE	DEG_SCF_FBW7_2	303:310	Mutation rewiring degron network	0.3056
p.R311I	ACH-000993	Endometrial/Uterine Cancer	CCLE	PNRTPSIT	DEG_SCF_FBW7_1	299:306	Mutation rewiring degron network	0.1944
p.R311I	ACH-000993	Endometrial/Uterine Cancer	CCLE	PSITPQEE	DEG_SCF_FBW7_2	303:310	Mutation rewiring degron network	0.3056
p.P837H	TCGA-AP-A0LM	UCEC	TCGA	NSLLEYSRQP	CBL_PTK	846:855	Mutation rewiring degron network	0.0833
p.P837H	DO43306	UCEC	ICGC	NSLLEYSRQP	CBL_PTK	846:855	Mutation rewiring degron network	0.0833
p.V842I	TCGA-AU-6004	COAD	TCGA	NSLLEYSRQP	CBL_PTK	846:855	Mutation rewiring degron network	0.2222
p.V842I	DO7780	COAD	ICGC	NSLLEYSRQP	CBL_PTK	846:855	Mutation rewiring degron network	0.2222
p.F289S	TCGA-AX-A2HD	UCEC	TCGA	PNRTPSIT	DEG_SCF_FBW7_1	299:306	Mutation rewiring degron network	0.0556
p.F289S	DO42608	UCEC	ICGC	PNRTPSIT	DEG_SCF_FBW7_1	299:306	Mutation rewiring degron network	0.0556
p.R844I	TCGA-BH-A6R9	BRCA	TCGA	NSLLEYSRQP	CBL_PTK	846:855	Mutation rewiring degron network	0.2778
p.R844I	DO219611	BRCA	ICGC	NSLLEYSRQP	CBL_PTK	846:855	Mutation rewiring degron network	0.2778
p.S847F	TCGA-BQ-5878	KIRP	TCGA	NSLLEYSRQP	CBL_PTK	846:855	Mutation altering degron motif	0.7982
p.S847F	DO20823	KIRP	ICGC	NSLLEYSRQP	CBL_PTK	846:855	Mutation altering degron motif	0.7982
p.S847F	DO222731	MELA	ICGC	NSLLEYSRQP	CBL_PTK	846:855	Mutation altering degron motif	0.7982
p.G746C	TCGA-BR-7851	STAD	TCGA	LKENE	DEG_APCC_KENBOX_2	737:741	Mutation rewiring degron network	0.1944
p.G746C	DO38711	STAD	ICGC	LKENE	DEG_APCC_KENBOX_2	737:741	Mutation rewiring degron network	0.1944
p.S364Y	TCGA-D3-A2JC	SKCM	TCGA	VSVHID	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.25
p.S364Y	DO47578	SKCM	ICGC	VSVHID	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.25
p.P749Q	TCGA-D3-A3CE	SKCM	TCGA	LKENE	DEG_APCC_KENBOX_2	737:741	Mutation rewiring degron network	0.1111
p.P749Q	DO37405	SKCM	ICGC	LKENE	DEG_APCC_KENBOX_2	737:741	Mutation rewiring degron network	0.1111
p.N747Y	TCGA-D3-A8GV	SKCM	TCGA	LKENE	DEG_APCC_KENBOX_2	737:741	Mutation rewiring degron network	0.1667
p.N747Y	DO219477	SKCM	ICGC	LKENE	DEG_APCC_KENBOX_2	737:741	Mutation rewiring degron network	0.1667
p.E271V	TCGA-DU-6392	LGG	TCGA	LCATPSLE	DEG_SCF_FBW7_2	258:265	Mutation rewiring degron network	0.1667
p.E271V	DO22237	LGG	ICGC	LCATPSLE	DEG_SCF_FBW7_2	258:265	Mutation rewiring degron network	0.1667
p.P729T	TCGA-DU-7298	LGG	TCGA	LKENE	DEG_APCC_KENBOX_2	737:741	Mutation rewiring degron network	0.1111
p.P729T	DO22679	LGG	ICGC	LKENE	DEG_APCC_KENBOX_2	737:741	Mutation rewiring degron network	0.1111
p.K296T	TCGA-E6-A1LX	UCEC	TCGA	PNRTPSIT	DEG_SCF_FBW7_1	299:306	Mutation substituting flanking lysine	0.3611
p.K296T	TCGA-E6-A1LX	UCEC	TCGA	PSITPQEE	DEG_SCF_FBW7_2	303:310	Mutation substituting flanking lysine	0.25
p.K296T	DO41020	UCEC	ICGC	PNRTPSIT	DEG_SCF_FBW7_1	299:306	Mutation substituting flanking lysine	0.3611
p.K296T	DO41020	UCEC	ICGC	PSITPQEE	DEG_SCF_FBW7_2	303:310	Mutation substituting flanking lysine	0.25
p.F297C	TCGA-F5-6814	READ	TCGA	PNRTPSIT	DEG_SCF_FBW7_1	299:306	Mutation rewiring degron network	0.2778
p.F297C	TCGA-F5-6814	READ	TCGA	PSITPQEE	DEG_SCF_FBW7_2	303:310	Mutation rewiring degron network	0.1667
p.F297C	DO222884	COCA	ICGC	PNRTPSIT	DEG_SCF_FBW7_1	299:306	Mutation rewiring degron network	0.2778
p.F297C	DO222884	COCA	ICGC	PSITPQEE	DEG_SCF_FBW7_2	303:310	Mutation rewiring degron network	0.1667
p.F297C	DO36556	READ	ICGC	PNRTPSIT	DEG_SCF_FBW7_1	299:306	Mutation rewiring degron network	0.2778
p.F297C	DO36556	READ	ICGC	PSITPQEE	DEG_SCF_FBW7_2	303:310	Mutation rewiring degron network	0.1667
p.P299H	DO222884	COCA	ICGC	PNRTPSIT	DEG_SCF_FBW7_1	299:306	Mutation altering degron motif	0.7694
p.G266S	DO233177	GACA	ICGC	LCATPSLE	DEG_SCF_FBW7_2	258:265	Mutation rewiring degron network	0.3056
p.Y272C	DO233871	GACA	ICGC	LCATPSLE	DEG_SCF_FBW7_2	258:265	Mutation rewiring degron network	0.1389
p.G857V	DO46929	RECA	ICGC	NSLLEYSRQP	CBL_PTK	846:855	Mutation rewiring degron network	0.2778
p.E271D	SIDM00683	Prostate Carcinoma	GDSC	LCATPSLE	DEG_SCF_FBW7_2	258:265	Mutation rewiring degron network	0.1667
p.E271D	ACH-000977	lymph node	CCLE	LCATPSLE	DEG_SCF_FBW7_2	258:265	Mutation rewiring degron network	0.1667
p.H858R	SIDM00938	Breast Carcinoma	GDSC	NSLLEYSRQP	CBL_PTK	846:855	Mutation rewiring degron network	0.25
p.H858R	CAL-148	breast	COSMIC	NSLLEYSRQP	CBL_PTK	846:855	Mutation rewiring degron network	0.25
p.A861S	SIDM00860	Head and Neck Carcinoma	GDSC	NSLLEYSRQP	CBL_PTK	846:855	Mutation rewiring degron network	0.1667
p.A861S	FADU	upper aerodigestive tract	COSMIC	NSLLEYSRQP	CBL_PTK	846:855	Mutation rewiring degron network	0.1667
p.N295T	SIDM00522	Small Cell Lung Carcinoma	GDSC	PNRTPSIT	DEG_SCF_FBW7_1	299:306	Mutation rewiring degron network	0.2222
p.N295T	SIDM00522	Small Cell Lung Carcinoma	GDSC	PSITPQEE	DEG_SCF_FBW7_2	303:310	Mutation rewiring degron network	0.1111
p.N295T	ACH-000749	Lung Cancer	CCLE	PNRTPSIT	DEG_SCF_FBW7_1	299:306	Mutation rewiring degron network	0.2222
p.N295T	ACH-000749	Lung Cancer	CCLE	PSITPQEE	DEG_SCF_FBW7_2	303:310	Mutation rewiring degron network	0.1111
p.N295T	DMS-273	lung	COSMIC	PNRTPSIT	DEG_SCF_FBW7_1	299:306	Mutation rewiring degron network	0.2222
p.N295T	DMS-273	lung	COSMIC	PSITPQEE	DEG_SCF_FBW7_2	303:310	Mutation rewiring degron network	0.1111
p.G377V	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VSVHID	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.1944
p.G377V	H513	pleura	COSMIC	VSVHID	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.1944
p.I249T	SIDM00948	Burkitt's Lymphoma	GDSC	LCATPSLE	DEG_SCF_FBW7_2	258:265	Mutation rewiring degron network	0.0833
p.I249T	ACH-002232	Lymphoma	CCLE	LCATPSLE	DEG_SCF_FBW7_2	258:265	Mutation rewiring degron network	0.0833
p.I249T	DG-75	haematopoietic and lymphoid tissue	COSMIC	LCATPSLE	DEG_SCF_FBW7_2	258:265	Mutation rewiring degron network	0.0833
p.N742T	SIDM00218	Thyroid Gland Carcinoma	GDSC	LKENE	DEG_APCC_KENBOX_2	737:741	Mutation rewiring degron network	0.3056
p.N742T	RO82-W-1	thyroid	COSMIC	LKENE	DEG_APCC_KENBOX_2	737:741	Mutation rewiring degron network	0.3056
p.P729S	SIDM00451	T-Lymphoblastic Leukemia	GDSC	LKENE	DEG_APCC_KENBOX_2	737:741	Mutation rewiring degron network	0.1111
p.P729S	PF-382	haematopoietic and lymphoid tissue	COSMIC	LKENE	DEG_APCC_KENBOX_2	737:741	Mutation rewiring degron network	0.1111
p.V271A	ACH-000304	Skin Cancer	CCLE	LCATPSLE	DEG_SCF_FBW7_2	258:265	Mutation rewiring degron network	0.1667
p.V271A	WM-115	skin	COSMIC	LCATPSLE	DEG_SCF_FBW7_2	258:265	Mutation rewiring degron network	0.1667
p.L248F	ACH-000620	Liver Cancer	CCLE	LCATPSLE	DEG_SCF_FBW7_2	258:265	Mutation substituting flanking lysine	0.1667
p.L248F	JHH-1	liver	COSMIC	LCATPSLE	DEG_SCF_FBW7_2	258:265	Mutation substituting flanking lysine	0.1667
p.V357L	ACH-000624	Breast Cancer	CCLE	VSVHID	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.0556
p.V357L	CAL-51	breast	COSMIC	VSVHID	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.0556
p.V357L	HCC1806	breast	COSMIC	VSVHID	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.0556
p.F739L	ACH-000991	Colon/Colorectal Cancer	CCLE	LKENE	DEG_APCC_KENBOX_2	737:741	Mutation altering degron motif	0.6981
p.F739L	SNU-81	large intestine	COSMIC	LKENE	DEG_APCC_KENBOX_2	737:741	Mutation altering degron motif	0.6981
p.P371L	ACH-001053	Brain Cancer	CCLE	VSVHID	LIG_APCC_ABBA_1	367:372	Mutation altering degron motif	0.7582
p.P371L	ACH-001054	Brain Cancer	CCLE	VSVHID	LIG_APCC_ABBA_1	367:372	Mutation altering degron motif	0.7582
p.P379L	ACH-001820	Breast Cancer	CCLE	VSVHID	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.1389
p.P379L	COLO-824	breast	COSMIC	VSVHID	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGAP11A

UniProt ID: Q6P4F7

Entrez ID: 9824

Protein name: Rho GTPase-activating protein 11A (Rho-type GTPase-activating protein 11A)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ARHGAP11A in