DegronMD

Uniprot ID: Q6P4F7

Source protein: Rho GTPase-activating protein 11A

Source gene: ARHGAP11A

Class: LIG_APCC_ABBA_1

Location: 367:372

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9274

ASA_SCORE: 83.25

COIL: 0.7473

CONS_SCORE: 0.4309

DSS_SCORE: 0.4703

HELIX: 0.0315

FCONS_SCORE: 0.9915

RIG_SCORE: 0.7265

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P371L	ACH-001053	Brain Cancer	CCLE	VSVHID	LIG_APCC_ABBA_1	0.7582
p.P371L	ACH-001054	Brain Cancer	CCLE	VSVHID	LIG_APCC_ABBA_1	0.7582
p.D372N	TCGA-A5-A2K3	UCEC	TCGA	VSVHID	LIG_APCC_ABBA_1	0.6932
p.D372N	TCGA-ER-A42L	SKCM	TCGA	VSVHID	LIG_APCC_ABBA_1	0.6932
p.D372N	DO223910	SKCM	ICGC	VSVHID	LIG_APCC_ABBA_1	0.6932
p.D372N	DO43899	UCEC	ICGC	VSVHID	LIG_APCC_ABBA_1	0.6932
p.S364Y	TCGA-D3-A2JC	SKCM	TCGA	VSVHID	LIG_APCC_ABBA_1	0.25
p.S364Y	DO47578	SKCM	ICGC	VSVHID	LIG_APCC_ABBA_1	0.25
p.G377V	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VSVHID	LIG_APCC_ABBA_1	0.1944
p.G377V	H513	pleura	COSMIC	VSVHID	LIG_APCC_ABBA_1	0.1944
p.P379L	ACH-001820	Breast Cancer	CCLE	VSVHID	LIG_APCC_ABBA_1	0.1389
p.P379L	COLO-824	breast	COSMIC	VSVHID	LIG_APCC_ABBA_1	0.1389
p.V357L	ACH-000624	Breast Cancer	CCLE	VSVHID	LIG_APCC_ABBA_1	0.0556
p.V357L	CAL-51	breast	COSMIC	VSVHID	LIG_APCC_ABBA_1	0.0556
p.V357L	HCC1806	breast	COSMIC	VSVHID	LIG_APCC_ABBA_1	0.0556

Showing 1 to 15 of 15 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P4F7	Rho GTPase-activating protein 11A	LIG_APCC_ABBA_1	367:372	VSVHID	APC,CDC20,FZR1	0.9274	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons