DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
NSLLEYSRQP
Uniprot ID:
Q6P4F7
Source protein:
Rho GTPase-activating protein 11A
Source gene:
ARHGAP11A
Class:
CBL_PTK
Location:
846:855
E3 ligase:
CBL
DEGRON score:
0.9895
ASA_SCORE:
92.38
COIL:
0.6799
CONS_SCORE:
0.3905
DSS_SCORE:
0.4119
HELIX:
0.16
FCONS_SCORE:
1.0042
RIG_SCORE:
0.7462
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R839C
TCGA-06-5416
GBM
TCGA
NSLLEYSRQP
CBL_PTK
0.1389
p.R839C
DO10880
GBM
ICGC
NSLLEYSRQP
CBL_PTK
0.1389
p.R839C
SIDM00118
Colorectal Carcinoma
GDSC
NSLLEYSRQP
CBL_PTK
0.1389
p.R839C
SIDM01588
Endometrial Carcinoma
GDSC
NSLLEYSRQP
CBL_PTK
0.1389
p.R839C
HCC2998
large_intestine
COSMIC
NSLLEYSRQP
CBL_PTK
0.1389
p.G857R
TCGA-96-A4JK
LUSC
TCGA
NSLLEYSRQP
CBL_PTK
0.2778
p.G857R
TCGA-UF-A71D
HNSC
TCGA
NSLLEYSRQP
CBL_PTK
0.2778
p.G857R
DO52109
HNSC
ICGC
NSLLEYSRQP
CBL_PTK
0.2778
p.G857R
DO45442
LUSC
ICGC
NSLLEYSRQP
CBL_PTK
0.2778
p.P837H
TCGA-AP-A0LM
UCEC
TCGA
NSLLEYSRQP
CBL_PTK
0.0833
p.P837H
DO43306
UCEC
ICGC
NSLLEYSRQP
CBL_PTK
0.0833
p.V842I
TCGA-AU-6004
COAD
TCGA
NSLLEYSRQP
CBL_PTK
0.2222
p.V842I
DO7780
COAD
ICGC
NSLLEYSRQP
CBL_PTK
0.2222
p.R844I
TCGA-BH-A6R9
BRCA
TCGA
NSLLEYSRQP
CBL_PTK
0.2778
p.R844I
DO219611
BRCA
ICGC
NSLLEYSRQP
CBL_PTK
0.2778
p.S847F
TCGA-BQ-5878
KIRP
TCGA
NSLLEYSRQP
CBL_PTK
0.7982
p.S847F
DO20823
KIRP
ICGC
NSLLEYSRQP
CBL_PTK
0.7982
p.S847F
DO222731
MELA
ICGC
NSLLEYSRQP
CBL_PTK
0.7982
p.G857V
DO46929
RECA
ICGC
NSLLEYSRQP
CBL_PTK
0.2778
p.H858R
SIDM00938
Breast Carcinoma
GDSC
NSLLEYSRQP
CBL_PTK
0.25
p.H858R
CAL-148
breast
COSMIC
NSLLEYSRQP
CBL_PTK
0.25
p.A861S
SIDM00860
Head and Neck Carcinoma
GDSC
NSLLEYSRQP
CBL_PTK
0.1667
p.A861S
FADU
upper_aerodigestive_tract
COSMIC
NSLLEYSRQP
CBL_PTK
0.1667
Drug responses associated with ARHGAP11A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NSLLEYSRQP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6P4F7
Rho GTPase-activating protein 11A
CBL_PTK
846:855
NSLLEYSRQP
CBL
0.9895
More...