DegronMD

Uniprot ID: Q6P4F7

Source protein: Rho GTPase-activating protein 11A

Source gene: ARHGAP11A

Class: DEG_SCF_FBW7_2

Location: 258:265

E3 ligase: FBXW7

DEGRON score: 0.9976

ASA_SCORE: 75.4625

COIL: 0.8731

CONS_SCORE: 0.4806

DSS_SCORE: 0.3072

HELIX: 0.0684

FCONS_SCORE: 1.0979

RIG_SCORE: 0.7653

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L258I	TCGA-AG-A002	READ	TCGA	LCATPSLE	DEG_SCF_FBW7_2	0.6063
p.E271V	TCGA-DU-6392	LGG	TCGA	LCATPSLE	DEG_SCF_FBW7_2	0.1667
p.E271V	DO22237	LGG	ICGC	LCATPSLE	DEG_SCF_FBW7_2	0.1667
p.G266S	DO233177	GACA	ICGC	LCATPSLE	DEG_SCF_FBW7_2	0.3056
p.Y272C	DO233871	GACA	ICGC	LCATPSLE	DEG_SCF_FBW7_2	0.1389
p.E271D	SIDM00683	Prostate Carcinoma	GDSC	LCATPSLE	DEG_SCF_FBW7_2	0.1667
p.E271D	ACH-000977	lymph_node	CCLE	LCATPSLE	DEG_SCF_FBW7_2	0.1667
p.I249T	SIDM00948	Burkitt's Lymphoma	GDSC	LCATPSLE	DEG_SCF_FBW7_2	0.0833
p.I249T	ACH-002232	Lymphoma	CCLE	LCATPSLE	DEG_SCF_FBW7_2	0.0833
p.I249T	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	LCATPSLE	DEG_SCF_FBW7_2	0.0833
p.V271A	ACH-000304	Skin Cancer	CCLE	LCATPSLE	DEG_SCF_FBW7_2	0.1667
p.V271A	WM-115	skin	COSMIC	LCATPSLE	DEG_SCF_FBW7_2	0.1667
p.L248F	ACH-000620	Liver Cancer	CCLE	LCATPSLE	DEG_SCF_FBW7_2	0.1667
p.L248F	JHH-1	liver	COSMIC	LCATPSLE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P4F7	Rho GTPase-activating protein 11A	DEG_SCF_FBW7_2	258:265	LCATPSLE	FBXW7	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons