DegronMD

Uniprot ID: Q6P4F7

Source protein: Rho GTPase-activating protein 11A

Source gene: ARHGAP11A

Class: DEG_SCF_FBW7_1

Location: 299:306

E3 ligase: FBXW7

DEGRON score: 0.9921

ASA_SCORE: 102.0625

COIL: 0.9543

CONS_SCORE: 0.3999

DSS_SCORE: 0.6099

HELIX: 0.0206

FCONS_SCORE: 1.0653

RIG_SCORE: 0.6787

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A313P	TCGA-AA-A01X	COAD	TCGA	PNRTPSIT	DEG_SCF_FBW7_1	0.1389
p.A313P	DO8004	COAD	ICGC	PNRTPSIT	DEG_SCF_FBW7_1	0.1389
p.R311I	TCGA-AP-A056	UCEC	TCGA	PNRTPSIT	DEG_SCF_FBW7_1	0.1944
p.R311I	TCGA-AX-A0J0	UCEC	TCGA	PNRTPSIT	DEG_SCF_FBW7_1	0.1944
p.R311I	TCGA-EO-A3AY	UCEC	TCGA	PNRTPSIT	DEG_SCF_FBW7_1	0.1944
p.R311I	DO43202	UCEC	ICGC	PNRTPSIT	DEG_SCF_FBW7_1	0.1944
p.R311I	DO41133	UCEC	ICGC	PNRTPSIT	DEG_SCF_FBW7_1	0.1944
p.R311I	DO43971	UCEC	ICGC	PNRTPSIT	DEG_SCF_FBW7_1	0.1944
p.R311I	SIDM01588	Endometrial Carcinoma	GDSC	PNRTPSIT	DEG_SCF_FBW7_1	0.1944
p.R311I	ACH-000993	Endometrial/Uterine Cancer	CCLE	PNRTPSIT	DEG_SCF_FBW7_1	0.1944
p.F289S	TCGA-AX-A2HD	UCEC	TCGA	PNRTPSIT	DEG_SCF_FBW7_1	0.0556
p.F289S	DO42608	UCEC	ICGC	PNRTPSIT	DEG_SCF_FBW7_1	0.0556
p.K296T	TCGA-E6-A1LX	UCEC	TCGA	PNRTPSIT	DEG_SCF_FBW7_1	0.3611
p.K296T	DO41020	UCEC	ICGC	PNRTPSIT	DEG_SCF_FBW7_1	0.3611
p.F297C	TCGA-F5-6814	READ	TCGA	PNRTPSIT	DEG_SCF_FBW7_1	0.2778
p.F297C	DO222884	COCA	ICGC	PNRTPSIT	DEG_SCF_FBW7_1	0.2778
p.F297C	DO36556	READ	ICGC	PNRTPSIT	DEG_SCF_FBW7_1	0.2778
p.P299H	DO222884	COCA	ICGC	PNRTPSIT	DEG_SCF_FBW7_1	0.7694
p.N295T	SIDM00522	Small Cell Lung Carcinoma	GDSC	PNRTPSIT	DEG_SCF_FBW7_1	0.2222
p.N295T	ACH-000749	Lung Cancer	CCLE	PNRTPSIT	DEG_SCF_FBW7_1	0.2222
p.N295T	DMS-273	lung	COSMIC	PNRTPSIT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P4F7	Rho GTPase-activating protein 11A	DEG_SCF_FBW7_1	299:306	PNRTPSIT	FBXW7	0.9921	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons