DegronMD

Uniprot ID: Q6P4F7

Source protein: Rho GTPase-activating protein 11A

Source gene: ARHGAP11A

Class: DEG_SCF_FBW7_2

Location: 303:310

E3 ligase: FBXW7

DEGRON score: 0.762

ASA_SCORE: 100.1625

COIL: 0.7676

CONS_SCORE: 0.37

DSS_SCORE: 0.6232

HELIX: 0.2126

FCONS_SCORE: 0.9474

RIG_SCORE: 0.7125

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A313P	TCGA-AA-A01X	COAD	TCGA	PSITPQEE	DEG_SCF_FBW7_2	0.25
p.A313P	DO8004	COAD	ICGC	PSITPQEE	DEG_SCF_FBW7_2	0.25
p.R311I	TCGA-AP-A056	UCEC	TCGA	PSITPQEE	DEG_SCF_FBW7_2	0.3056
p.R311I	TCGA-AX-A0J0	UCEC	TCGA	PSITPQEE	DEG_SCF_FBW7_2	0.3056
p.R311I	TCGA-EO-A3AY	UCEC	TCGA	PSITPQEE	DEG_SCF_FBW7_2	0.3056
p.R311I	DO43202	UCEC	ICGC	PSITPQEE	DEG_SCF_FBW7_2	0.3056
p.R311I	DO41133	UCEC	ICGC	PSITPQEE	DEG_SCF_FBW7_2	0.3056
p.R311I	DO43971	UCEC	ICGC	PSITPQEE	DEG_SCF_FBW7_2	0.3056
p.R311I	SIDM01588	Endometrial Carcinoma	GDSC	PSITPQEE	DEG_SCF_FBW7_2	0.3056
p.R311I	ACH-000993	Endometrial/Uterine Cancer	CCLE	PSITPQEE	DEG_SCF_FBW7_2	0.3056
p.K296T	TCGA-E6-A1LX	UCEC	TCGA	PSITPQEE	DEG_SCF_FBW7_2	0.25
p.K296T	DO41020	UCEC	ICGC	PSITPQEE	DEG_SCF_FBW7_2	0.25
p.F297C	TCGA-F5-6814	READ	TCGA	PSITPQEE	DEG_SCF_FBW7_2	0.1667
p.F297C	DO222884	COCA	ICGC	PSITPQEE	DEG_SCF_FBW7_2	0.1667
p.F297C	DO36556	READ	ICGC	PSITPQEE	DEG_SCF_FBW7_2	0.1667
p.N295T	SIDM00522	Small Cell Lung Carcinoma	GDSC	PSITPQEE	DEG_SCF_FBW7_2	0.1111
p.N295T	ACH-000749	Lung Cancer	CCLE	PSITPQEE	DEG_SCF_FBW7_2	0.1111
p.N295T	DMS-273	lung	COSMIC	PSITPQEE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P4F7	Rho GTPase-activating protein 11A	DEG_SCF_FBW7_2	303:310	PSITPQEE	FBXW7	0.762	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons