DegronMD

Uniprot ID: Q6P4F7

Source protein: Rho GTPase-activating protein 11A

Source gene: ARHGAP11A

Class: DEG_APCC_KENBOX_2

Location: 737:741

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8239

ASA_SCORE: 104.7

COIL: 0.5856

CONS_SCORE: 0.2903

DSS_SCORE: 0.6663

HELIX: 0.2958

FCONS_SCORE: 1.0554

RIG_SCORE: 0.6994

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N747K	TCGA-86-7713	LUAD	TCGA	LKENE	DEG_APCC_KENBOX_2	0.1667
p.N747K	DO24712	LUAD	ICGC	LKENE	DEG_APCC_KENBOX_2	0.1667
p.G746C	TCGA-BR-7851	STAD	TCGA	LKENE	DEG_APCC_KENBOX_2	0.1944
p.G746C	DO38711	STAD	ICGC	LKENE	DEG_APCC_KENBOX_2	0.1944
p.P749Q	TCGA-D3-A3CE	SKCM	TCGA	LKENE	DEG_APCC_KENBOX_2	0.1111
p.P749Q	DO37405	SKCM	ICGC	LKENE	DEG_APCC_KENBOX_2	0.1111
p.N747Y	TCGA-D3-A8GV	SKCM	TCGA	LKENE	DEG_APCC_KENBOX_2	0.1667
p.N747Y	DO219477	SKCM	ICGC	LKENE	DEG_APCC_KENBOX_2	0.1667
p.P729T	TCGA-DU-7298	LGG	TCGA	LKENE	DEG_APCC_KENBOX_2	0.1111
p.P729T	DO22679	LGG	ICGC	LKENE	DEG_APCC_KENBOX_2	0.1111
p.N742T	SIDM00218	Thyroid Gland Carcinoma	GDSC	LKENE	DEG_APCC_KENBOX_2	0.3056
p.N742T	RO82-W-1	thyroid	COSMIC	LKENE	DEG_APCC_KENBOX_2	0.3056
p.P729S	SIDM00451	T-Lymphoblastic Leukemia	GDSC	LKENE	DEG_APCC_KENBOX_2	0.1111
p.P729S	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	LKENE	DEG_APCC_KENBOX_2	0.1111
p.F739L	ACH-000991	Colon/Colorectal Cancer	CCLE	LKENE	DEG_APCC_KENBOX_2	0.6981
p.F739L	SNU-81	large_intestine	COSMIC	LKENE	DEG_APCC_KENBOX_2	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6IQ26	DENN domain-containing protein 5A	DEG_APCC_KENBOX_2	463:467	LKENE	APC,CDC20,FZR1	0.7918	More...
Q6P4F7	Rho GTPase-activating protein 11A	DEG_APCC_KENBOX_2	737:741	LKENE	APC,CDC20,FZR1	0.8239	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons