GDF6
UniProt ID: Q6KF10
Entrez ID: 392255
Protein name: Growth/differentiation factor 6 (GDF-6) (Bone morphogenetic protein 13) (BMP-13) (Growth/differentiation factor 16)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map (...
FUNCTION: Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map (PubMed:23307924). Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal structures. Seems to positively regulate differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A, leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG (PubMed:26643732). Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38 (By similarity). {ECO:0000250|UniProtKB:P43028, ECO:0000269|PubMed:23307924, ECO:0000269|PubMed:26643732}.
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GO - Biological processes (BP):
activin receptor signaling pathway [GO:0032924]; apoptotic process [GO:0006915]; BMP signaling pathway [GO:0030509]; cell migration involved in metanephros development [GO:0035788]; fat cell differentiation [GO:0045444]; metanephros development [GO:0001656]; pathway-restricted SMAD protein phosphory...
activin receptor signaling pathway [GO:0032924]; apoptotic process [GO:0006915]; BMP signaling pathway [GO:0030509]; cell migration involved in metanephros development [GO:0035788]; fat cell differentiation [GO:0045444]; metanephros development [GO:0001656]; pathway-restricted SMAD protein phosphorylation [GO:0060389]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; positive regulation of transcription, DNA-templated [GO:0045893]; retinal cell apoptotic process [GO:1990009]; SMAD protein signal transduction [GO:0060395]
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GO - Molecular function (MF):
cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]...
cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]
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GO - Cellular component (CC):
extracellular space [GO:0005615]...
extracellular space [GO:0005615]
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GDF6
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Kaplan plot for GDF6 in
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*NOTE: the Kaplan plots were collected from OncoLnc