DegronMD

Uniprot ID: Q6KF10

Source protein: Growth/differentiation factor 6

Source gene: GDF6

Class: LIG_APCC_ABBAyCdc20_2

Location: 286:292

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6456

ASA_SCORE: 96.4143

COIL: 0.3909

CONS_SCORE: 0.5418

DSS_SCORE: 0.399

HELIX: 0.5931

FCONS_SCORE: 1.1243

RIG_SCORE: 0.808

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G298C	TCGA-77-8144	LUSC	TCGA	RKNLFAE	LIG_APCC_ABBAyCdc20_2	0.1667
p.G298C	DO26949	LUSC	ICGC	RKNLFAE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R286H	TCGA-HU-A4GU	STAD	TCGA	RKNLFAE	LIG_APCC_ABBAyCdc20_2	0.8244
p.R286H	DO47849	STAD	ICGC	RKNLFAE	LIG_APCC_ABBAyCdc20_2	0.8244
p.R286H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	RKNLFAE	LIG_APCC_ABBAyCdc20_2	0.8244
p.R286H	ACH-002256	Leukemia	CCLE	RKNLFAE	LIG_APCC_ABBAyCdc20_2	0.8244
p.R286H	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	RKNLFAE	LIG_APCC_ABBAyCdc20_2	0.8244
p.A276V	DO37424	SKCM	ICGC	RKNLFAE	LIG_APCC_ABBAyCdc20_2	0.0556
p.L289P	SIDM00529	Breast Carcinoma	GDSC	RKNLFAE	LIG_APCC_ABBAyCdc20_2	0.7582
p.T282A	SIDM00282	Colorectal Carcinoma	GDSC	RKNLFAE	LIG_APCC_ABBAyCdc20_2	0.2222
p.T282A	ACH-000998	Colon/Colorectal Cancer	CCLE	RKNLFAE	LIG_APCC_ABBAyCdc20_2	0.2222
p.T282A	CW-2	large_intestine	COSMIC	RKNLFAE	LIG_APCC_ABBAyCdc20_2	0.2222
p.E295D	ACH-000679	Esophageal Cancer	CCLE	RKNLFAE	LIG_APCC_ABBAyCdc20_2	0.25
p.R294H	ACH-000939	Sarcoma	CCLE	RKNLFAE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R294L	ACH-000945	Lung Cancer	CCLE	RKNLFAE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R286L	ACH-000945	Lung Cancer	CCLE	RKNLFAE	LIG_APCC_ABBAyCdc20_2	0.8428
p.E295K	ACH-000982	Colon/Colorectal Cancer	CCLE	RKNLFAE	LIG_APCC_ABBAyCdc20_2	0.25
p.E295K	ACH-001345	Colon/Colorectal Cancer	CCLE	RKNLFAE	LIG_APCC_ABBAyCdc20_2	0.25
p.Q285H	ACH-001399	Colon/Colorectal Cancer	CCLE	RKNLFAE	LIG_APCC_ABBAyCdc20_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6KF10	Growth/differentiation factor 6	LIG_APCC_ABBAyCdc20_2	286:292	RKNLFAE	APC,CDC20,FZR1	0.6456	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons