DegronMD - Q6L9W6(B4GALNT3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R323Q	TCGA-22-5480	LUSC	TCGA	PRDTLYRVP	DEG_APCC_DBOX_1	326:334	Mutation rewiring degron network	0.25
p.R323Q	DO26786	LUSC	ICGC	PRDTLYRVP	DEG_APCC_DBOX_1	326:334	Mutation rewiring degron network	0.25
p.P337S	TCGA-63-A5MU	LUSC	TCGA	PRDTLYRVP	DEG_APCC_DBOX_1	326:334	Mutation rewiring degron network	0.25
p.P337S	DO219165	LUSC	ICGC	PRDTLYRVP	DEG_APCC_DBOX_1	326:334	Mutation rewiring degron network	0.25
p.R332L	TCGA-EE-A183	SKCM	TCGA	PRDTLYRVP	DEG_APCC_DBOX_1	326:334	Mutation altering degron motif	0.7316
p.R332L	DO37715	SKCM	ICGC	PRDTLYRVP	DEG_APCC_DBOX_1	326:334	Mutation altering degron motif	0.7316
p.R342H	DO225216	BRCA	ICGC	PRDTLYRVP	DEG_APCC_DBOX_1	326:334	Mutation rewiring degron network	0.1111
p.R342H	DO227480	BRCA	ICGC	PRDTLYRVP	DEG_APCC_DBOX_1	326:334	Mutation rewiring degron network	0.1111
p.A319V	DO222794	COCA	ICGC	PRDTLYRVP	DEG_APCC_DBOX_1	326:334	Mutation rewiring degron network	0.1389
p.I336L	DO234383	ESAD	ICGC	PRDTLYRVP	DEG_APCC_DBOX_1	326:334	Mutation rewiring degron network	0.2778
p.L341P	DO233791	GACA	ICGC	PRDTLYRVP	DEG_APCC_DBOX_1	326:334	Mutation rewiring degron network	0.1389
p.V333A	SIDM00232	Kidney Carcinoma	GDSC	PRDTLYRVP	DEG_APCC_DBOX_1	326:334	Mutation altering degron motif	0.6936
p.V333A	NCC021	kidney	COSMIC	PRDTLYRVP	DEG_APCC_DBOX_1	326:334	Mutation altering degron motif	0.6936
p.R327W	SIDM00683	Prostate Carcinoma	GDSC	PRDTLYRVP	DEG_APCC_DBOX_1	326:334	Mutation altering degron motif	0.8634
p.R327W	ACH-000977	lymph node	CCLE	PRDTLYRVP	DEG_APCC_DBOX_1	326:334	Mutation altering degron motif	0.8634
p.R327W	LNCaP-Clone-FGC	prostate	COSMIC	PRDTLYRVP	DEG_APCC_DBOX_1	326:334	Mutation altering degron motif	0.8634
p.Y331C	ACH-000961	Endometrial/Uterine Cancer	CCLE	PRDTLYRVP	DEG_APCC_DBOX_1	326:334	Mutation altering degron motif	0.5976
p.P334S	ACH-001991	Primary	CCLE	PRDTLYRVP	DEG_APCC_DBOX_1	326:334	Mutation altering degron motif	0.5641

Kaplan plot for B4GALNT3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

B4GALNT3

UniProt ID: Q6L9W6

Entrez ID: 283358

Protein name: Beta-1,4-N-acetylgalactosaminyltransferase 3 (B4GalNAcT3) (Beta4GalNAc-T3) (Beta4GalNAcT3) (EC 2.4.1.244) (Beta-1,4-N-acetylgalactosaminyltransferase III) (N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 2) (NGalNAc-T2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for B4GALNT3 in