DegronMD

Uniprot ID: Q6L9W6

Source protein: Beta-1,4-N-acetylgalactosaminyltransferase 3

Source gene: B4GALNT3

Class: DEG_APCC_DBOX_1

Location: 326:334

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.696

ASA_SCORE: 55.0333

COIL: 0.6522

CONS_SCORE: 0.4139

DSS_SCORE: 0.4683

HELIX: 0.1636

FCONS_SCORE: 1.0263

RIG_SCORE: 0.7476

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R323Q	TCGA-22-5480	LUSC	TCGA	PRDTLYRVP	DEG_APCC_DBOX_1	0.25
p.R323Q	DO26786	LUSC	ICGC	PRDTLYRVP	DEG_APCC_DBOX_1	0.25
p.P337S	TCGA-63-A5MU	LUSC	TCGA	PRDTLYRVP	DEG_APCC_DBOX_1	0.25
p.P337S	DO219165	LUSC	ICGC	PRDTLYRVP	DEG_APCC_DBOX_1	0.25
p.R332L	TCGA-EE-A183	SKCM	TCGA	PRDTLYRVP	DEG_APCC_DBOX_1	0.7316
p.R332L	DO37715	SKCM	ICGC	PRDTLYRVP	DEG_APCC_DBOX_1	0.7316
p.R342H	DO225216	BRCA	ICGC	PRDTLYRVP	DEG_APCC_DBOX_1	0.1111
p.R342H	DO227480	BRCA	ICGC	PRDTLYRVP	DEG_APCC_DBOX_1	0.1111
p.A319V	DO222794	COCA	ICGC	PRDTLYRVP	DEG_APCC_DBOX_1	0.1389
p.I336L	DO234383	ESAD	ICGC	PRDTLYRVP	DEG_APCC_DBOX_1	0.2778
p.L341P	DO233791	GACA	ICGC	PRDTLYRVP	DEG_APCC_DBOX_1	0.1389
p.V333A	SIDM00232	Kidney Carcinoma	GDSC	PRDTLYRVP	DEG_APCC_DBOX_1	0.6936
p.V333A	NCC021	kidney	COSMIC	PRDTLYRVP	DEG_APCC_DBOX_1	0.6936
p.R327W	SIDM00683	Prostate Carcinoma	GDSC	PRDTLYRVP	DEG_APCC_DBOX_1	0.8634
p.R327W	ACH-000977	lymph_node	CCLE	PRDTLYRVP	DEG_APCC_DBOX_1	0.8634
p.R327W	LNCaP-Clone-FGC	prostate	COSMIC	PRDTLYRVP	DEG_APCC_DBOX_1	0.8634
p.Y331C	ACH-000961	Endometrial/Uterine Cancer	CCLE	PRDTLYRVP	DEG_APCC_DBOX_1	0.5976
p.P334S	ACH-001991	Primary	CCLE	PRDTLYRVP	DEG_APCC_DBOX_1	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6L9W6	Beta-1,4-N-acetylgalactosaminyltransferase 3	DEG_APCC_DBOX_1	326:334	PRDTLYRVP	APC,CDC20,FZR1	0.696	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons