DegronMD - Q6NS38(ALKBH2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V240M	TCGA-AX-A2HD	UCEC	TCGA	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	245:258	Mutation rewiring degron network	0.1944
p.V240M	DO42608	UCEC	ICGC	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	245:258	Mutation rewiring degron network	0.1944
p.K242M	TCGA-DS-A1OC	CESC	TCGA	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	245:258	Mutation substituting flanking lysine	0.3611
p.K242M	DO6329	CESC	ICGC	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	245:258	Mutation substituting flanking lysine	0.3611
p.S237R	TCGA-ED-A459	LIHC	TCGA	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	245:258	Mutation rewiring degron network	0.1111
p.S237R	DO44974	LIHC	ICGC	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	245:258	Mutation rewiring degron network	0.1111
p.K261T	TCGA-EO-A3AY	UCEC	TCGA	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	245:258	Mutation substituting flanking lysine	0.3611
p.K261T	DO43202	UCEC	ICGC	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	245:258	Mutation substituting flanking lysine	0.3611
p.R254C	TCGA-KL-8323	KICH	TCGA	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	245:258	Mutation altering degron motif	0.719
p.R254C	DO220331	KICH	ICGC	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	245:258	Mutation altering degron motif	0.719
p.P239R	TCGA-L5-A8NE	ESCA	TCGA	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	245:258	Mutation rewiring degron network	0.1667
p.Y235H	SIDM00537	Colorectal Carcinoma	GDSC	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	245:258	Mutation rewiring degron network	0.0556
p.Y235H	ACH-000982	Colon/Colorectal Cancer	CCLE	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	245:258	Mutation rewiring degron network	0.0556
p.Y235H	ACH-001345	Colon/Colorectal Cancer	CCLE	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	245:258	Mutation rewiring degron network	0.0556
p.Y235H	GP5d	large intestine	COSMIC	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	245:258	Mutation rewiring degron network	0.0556
p.R254H	SIDM00534	Colorectal Carcinoma	GDSC	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	245:258	Mutation altering degron motif	0.7133
p.R254H	ACH-000986	Colon/Colorectal Cancer	CCLE	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	245:258	Mutation altering degron motif	0.7133
p.R254H	HT-115	large intestine	COSMIC	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	245:258	Mutation altering degron motif	0.7133
p.V244I	SIDM01693	B-Lymphoblastic Leukemia	GDSC	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	245:258	Mutation rewiring degron network	0.3056

Kaplan plot for ALKBH2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ALKBH2

UniProt ID: Q6NS38

Entrez ID: 121642

Protein name: DNA oxidative demethylase ALKBH2 (EC 1.14.11.33) (Alkylated DNA repair protein alkB homolog 2) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2) (Oxy DC1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ALKBH2 in