DegronMD

Uniprot ID: Q6NS38

Source protein: DNA oxidative demethylase ALKBH2

Source gene: ALKBH2

Class: DEG_ODPH_VHL_1

Location: 245:258

E3 ligase: VHL

DEGRON score: 0.5345

ASA_SCORE: 47.4357

COIL: 0.4357

CONS_SCORE: 0.6948

DSS_SCORE: 0.2647

HELIX: 0.0479

FCONS_SCORE: 1.1546

RIG_SCORE: 0.8913

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R254C	TCGA-KL-8323	KICH	TCGA	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	0.719
p.R254C	DO220331	KICH	ICGC	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	0.719
p.R254H	SIDM00534	Colorectal Carcinoma	GDSC	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	0.7133
p.R254H	ACH-000986	Colon/Colorectal Cancer	CCLE	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	0.7133
p.R254H	HT-115	large_intestine	COSMIC	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	0.7133
p.K242M	TCGA-DS-A1OC	CESC	TCGA	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	0.3611
p.K242M	DO6329	CESC	ICGC	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	0.3611
p.K261T	TCGA-EO-A3AY	UCEC	TCGA	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	0.3611
p.K261T	DO43202	UCEC	ICGC	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	0.3611
p.V244I	SIDM01693	B-Lymphoblastic Leukemia	GDSC	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	0.3056
p.V240M	TCGA-AX-A2HD	UCEC	TCGA	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	0.1944
p.V240M	DO42608	UCEC	ICGC	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	0.1944
p.P239R	TCGA-L5-A8NE	ESCA	TCGA	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	0.1667
p.S237R	TCGA-ED-A459	LIHC	TCGA	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	0.1111
p.S237R	DO44974	LIHC	ICGC	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	0.1111
p.Y235H	SIDM00537	Colorectal Carcinoma	GDSC	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	0.0556
p.Y235H	ACH-000982	Colon/Colorectal Cancer	CCLE	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	0.0556
p.Y235H	ACH-001345	Colon/Colorectal Cancer	CCLE	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	0.0556
p.Y235H	GP5d	large_intestine	COSMIC	LAPRVNLTFRKILL	DEG_ODPH_VHL_1	0.0556

Showing 1 to 19 of 19 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6NS38	DNA oxidative demethylase ALKBH2	DEG_ODPH_VHL_1	245:258	LAPRVNLTFRKILL	VHL	0.5345	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons