DegronMD - Q6NT55(CYP4F22)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R460H	TCGA-A5-A0G1	UCEC	TCGA	QRSPLAYVP	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.8244
p.R460H	TCGA-FI-A2D5	UCEC	TCGA	QRSPLAYVP	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.8244
p.R460H	DO42472	UCEC	ICGC	QRSPLAYVP	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.8244
p.R460H	DO41331	UCEC	ICGC	QRSPLAYVP	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.8244
p.R460H	SIDM00499	Prostate Carcinoma	GDSC	QRSPLAYVP	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.8244
p.R460H	ACH-000956	Prostate Cancer	CCLE	QRSPLAYVP	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.8244
p.R460H	22RV1	prostate	COSMIC	QRSPLAYVP	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.8244
p.V466A	TCGA-FI-A2D5	UCEC	TCGA	QRSPLAYVP	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.6936
p.V466A	DO41331	UCEC	ICGC	QRSPLAYVP	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.6936
p.V466M	TCGA-HU-A4GN	STAD	TCGA	QRSPLAYVP	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.6097
p.V466M	DO47833	STAD	ICGC	QRSPLAYVP	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.6097
p.D453Y	TCGA-XF-A9SY	BLCA	TCGA	QRSPLAYVP	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.1667
p.D453Y	DO51918	BLCA	ICGC	QRSPLAYVP	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.1667
p.F468L	DO50411	ESAD	ICGC	QRSPLAYVP	DEG_APCC_DBOX_1	459:467	Mutation rewiring degron network	0.3056
p.Q459R	DO233652	GACA	ICGC	QRSPLAYVP	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.6218
p.R460C	SIDM00783	Colorectal Carcinoma	GDSC	QRSPLAYVP	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.8301
p.R460C	ACH-000971	Colon/Colorectal Cancer	CCLE	QRSPLAYVP	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.8301
p.R460C	HCT-116	large intestine	COSMIC	QRSPLAYVP	DEG_APCC_DBOX_1	459:467	Mutation altering degron motif	0.8301

Kaplan plot for CYP4F22 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CYP4F22

UniProt ID: Q6NT55

Entrez ID: 126410

Protein name: Ultra-long-chain fatty acid omega-hydroxylase (EC 1.14.14.177) (Cytochrome P450 4F22)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CYP4F22 in