DegronMD

Uniprot ID: Q6NT55

Source protein: Ultra-long-chain fatty acid omega-hydroxylase

Source gene: CYP4F22

Class: DEG_APCC_DBOX_1

Location: 459:467

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8155

ASA_SCORE: 38.3333

COIL: 0.867

CONS_SCORE: 0.501

DSS_SCORE: 0.4213

HELIX: 0.0668

FCONS_SCORE: 0.7835

RIG_SCORE: 0.7502

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R460H	TCGA-A5-A0G1	UCEC	TCGA	QRSPLAYVP	DEG_APCC_DBOX_1	0.8244
p.R460H	TCGA-FI-A2D5	UCEC	TCGA	QRSPLAYVP	DEG_APCC_DBOX_1	0.8244
p.R460H	DO42472	UCEC	ICGC	QRSPLAYVP	DEG_APCC_DBOX_1	0.8244
p.R460H	DO41331	UCEC	ICGC	QRSPLAYVP	DEG_APCC_DBOX_1	0.8244
p.R460H	SIDM00499	Prostate Carcinoma	GDSC	QRSPLAYVP	DEG_APCC_DBOX_1	0.8244
p.R460H	ACH-000956	Prostate Cancer	CCLE	QRSPLAYVP	DEG_APCC_DBOX_1	0.8244
p.R460H	22RV1	prostate	COSMIC	QRSPLAYVP	DEG_APCC_DBOX_1	0.8244
p.V466A	TCGA-FI-A2D5	UCEC	TCGA	QRSPLAYVP	DEG_APCC_DBOX_1	0.6936
p.V466A	DO41331	UCEC	ICGC	QRSPLAYVP	DEG_APCC_DBOX_1	0.6936
p.V466M	TCGA-HU-A4GN	STAD	TCGA	QRSPLAYVP	DEG_APCC_DBOX_1	0.6097
p.V466M	DO47833	STAD	ICGC	QRSPLAYVP	DEG_APCC_DBOX_1	0.6097
p.D453Y	TCGA-XF-A9SY	BLCA	TCGA	QRSPLAYVP	DEG_APCC_DBOX_1	0.1667
p.D453Y	DO51918	BLCA	ICGC	QRSPLAYVP	DEG_APCC_DBOX_1	0.1667
p.F468L	DO50411	ESAD	ICGC	QRSPLAYVP	DEG_APCC_DBOX_1	0.3056
p.Q459R	DO233652	GACA	ICGC	QRSPLAYVP	DEG_APCC_DBOX_1	0.6218
p.R460C	SIDM00783	Colorectal Carcinoma	GDSC	QRSPLAYVP	DEG_APCC_DBOX_1	0.8301
p.R460C	ACH-000971	Colon/Colorectal Cancer	CCLE	QRSPLAYVP	DEG_APCC_DBOX_1	0.8301
p.R460C	HCT-116	large_intestine	COSMIC	QRSPLAYVP	DEG_APCC_DBOX_1	0.8301

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6NT55	Ultra-long-chain fatty acid omega-hydroxylase	DEG_APCC_DBOX_1	459:467	QRSPLAYVP	APC,CDC20,FZR1	0.8155	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons