DegronMD - Q6NUN7(JHY)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E156G	SIDM02050	Colorectal Carcinoma	GDSC	LAPLYPSQETSMEL	DEG_ODPH_VHL_1	160:173	Mutation rewiring degron network	0.2222
p.S170P	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	LAPLYPSQETSMEL	DEG_ODPH_VHL_1	160:173	Mutation altering degron motif	0.5641
p.S170P	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	LAPLYPSQETSMEL	DEG_ODPH_VHL_1	160:173	Mutation altering degron motif	0.5641
p.Q167R	SIDM00535	Chondrosarcoma	GDSC	LAPLYPSQETSMEL	DEG_ODPH_VHL_1	160:173	Mutation altering degron motif	0.6218
p.Q167R	SIDM00290	Gastric Carcinoma	GDSC	LAPLYPSQETSMEL	DEG_ODPH_VHL_1	160:173	Mutation altering degron motif	0.6218
p.Q167R	HGC-27	stomach	COSMIC	LAPLYPSQETSMEL	DEG_ODPH_VHL_1	160:173	Mutation altering degron motif	0.6218
p.Q167R	H-EMC-SS	bone	COSMIC	LAPLYPSQETSMEL	DEG_ODPH_VHL_1	160:173	Mutation altering degron motif	0.6218
p.G175R	SIDM00282	Colorectal Carcinoma	GDSC	LAPLYPSQETSMEL	DEG_ODPH_VHL_1	160:173	Mutation rewiring degron network	0.2778
p.G175R	CW-2	large intestine	COSMIC	LAPLYPSQETSMEL	DEG_ODPH_VHL_1	160:173	Mutation rewiring degron network	0.2778

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons