DegronMD

Uniprot ID: Q6NUN7

Source protein: Jhy protein homolog

Source gene: JHY

Class: DEG_ODPH_VHL_1

Location: 160:173

E3 ligase: VHL

DEGRON score: 0.695

ASA_SCORE: 87.4786

COIL: 0.7964

CONS_SCORE: 0.6354

DSS_SCORE: 0.632

HELIX: 0.1301

FCONS_SCORE: 1.0348

RIG_SCORE: 0.6769

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E156G	SIDM02050	Colorectal Carcinoma	GDSC	LAPLYPSQETSMEL	DEG_ODPH_VHL_1	0.2222
p.S170P	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	LAPLYPSQETSMEL	DEG_ODPH_VHL_1	0.5641
p.S170P	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LAPLYPSQETSMEL	DEG_ODPH_VHL_1	0.5641
p.Q167R	SIDM00535	Chondrosarcoma	GDSC	LAPLYPSQETSMEL	DEG_ODPH_VHL_1	0.6218
p.Q167R	SIDM00290	Gastric Carcinoma	GDSC	LAPLYPSQETSMEL	DEG_ODPH_VHL_1	0.6218
p.Q167R	HGC-27	stomach	COSMIC	LAPLYPSQETSMEL	DEG_ODPH_VHL_1	0.6218
p.Q167R	H-EMC-SS	bone	COSMIC	LAPLYPSQETSMEL	DEG_ODPH_VHL_1	0.6218
p.G175R	SIDM00282	Colorectal Carcinoma	GDSC	LAPLYPSQETSMEL	DEG_ODPH_VHL_1	0.2778
p.G175R	CW-2	large_intestine	COSMIC	LAPLYPSQETSMEL	DEG_ODPH_VHL_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6NUN7	Jhy protein homolog	DEG_ODPH_VHL_1	160:173	LAPLYPSQETSMEL	VHL	0.695	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons