DegronMD - Q6NUN9(ZNF746)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q417L	TCGA-05-4410	LUAD	TCGA	SPDNGE	DEG_Kelch_Keap1_1	404:409	Mutation rewiring degron network	0.1111
p.P394Q	TCGA-EE-A183	SKCM	TCGA	SPDNGE	DEG_Kelch_Keap1_1	404:409	Mutation rewiring degron network	0.0556
p.P402H	TCGA-EE-A2GE	SKCM	TCGA	SPDNGE	DEG_Kelch_Keap1_1	404:409	Mutation rewiring degron network	0.2778
p.E398K	DO225215	BRCA	ICGC	SPDNGE	DEG_Kelch_Keap1_1	404:409	Mutation rewiring degron network	0.1667
p.E398K	DO227836	BRCA	ICGC	SPDNGE	DEG_Kelch_Keap1_1	404:409	Mutation rewiring degron network	0.1667
p.T395M	DO222960	BTCA	ICGC	SPDNGE	DEG_Kelch_Keap1_1	404:409	Mutation rewiring degron network	0.0833
p.P397T	DO229041	LICA	ICGC	SPDNGE	DEG_Kelch_Keap1_1	404:409	Mutation rewiring degron network	0.1389
p.Q416L	DO25426	LUAD	ICGC	SPDNGE	DEG_Kelch_Keap1_1	404:409	Mutation rewiring degron network	0.1389
p.P401H	DO38016	SKCM	ICGC	SPDNGE	DEG_Kelch_Keap1_1	404:409	Mutation rewiring degron network	0.25
p.G395D	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	SPDNGE	DEG_Kelch_Keap1_1	404:409	Mutation rewiring degron network	0.0833
p.G395D	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	SPDNGE	DEG_Kelch_Keap1_1	404:409	Mutation rewiring degron network	0.0833
p.G411E	SIDM01198	Burkitt's Lymphoma	GDSC	SPDNGE	DEG_Kelch_Keap1_1	404:409	Mutation rewiring degron network	0.2778
p.R399Q	SIDM00889	Cervical Carcinoma	GDSC	SPDNGE	DEG_Kelch_Keap1_1	404:409	Mutation rewiring degron network	0.1944
p.R399Q	C-33-A	cervix	COSMIC	SPDNGE	DEG_Kelch_Keap1_1	404:409	Mutation rewiring degron network	0.1944
p.W394C	SIDM00596	Endometrial Carcinoma	GDSC	SPDNGE	DEG_Kelch_Keap1_1	404:409	Mutation rewiring degron network	0.0556
p.W394C	HEC-1	endometrium	COSMIC	SPDNGE	DEG_Kelch_Keap1_1	404:409	Mutation rewiring degron network	0.0556
p.P408L	SIDM00140	Melanoma	GDSC	SPDNGE	DEG_Kelch_Keap1_1	404:409	Mutation altering degron motif	0.7582
p.P408L	COLO-792	skin	COSMIC	SPDNGE	DEG_Kelch_Keap1_1	404:409	Mutation altering degron motif	0.7582
p.P394L	ACH-000968	Skin Cancer	CCLE	SPDNGE	DEG_Kelch_Keap1_1	404:409	Mutation rewiring degron network	0.0556
p.P394L	COLO-792	skin	COSMIC	SPDNGE	DEG_Kelch_Keap1_1	404:409	Mutation rewiring degron network	0.0556

Kaplan plot for ZNF746 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF746

UniProt ID: Q6NUN9

Entrez ID: 155061

Protein name: Zinc finger protein 746 (Parkin-interacting substrate) (PARIS)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF746 in