DegronMD

Uniprot ID: Q6NUN9

Source protein: Zinc finger protein 746

Source gene: ZNF746

Class: DEG_Kelch_Keap1_1

Location: 404:409

E3 ligase: KEAP1

DEGRON score: 0.8746

ASA_SCORE: 59.4333

COIL: 0.7743

CONS_SCORE: 0.6232

DSS_SCORE: 0.6645

HELIX: 0.1828

FCONS_SCORE: 1.0042

RIG_SCORE: 0.606

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q417L	TCGA-05-4410	LUAD	TCGA	SPDNGE	DEG_Kelch_Keap1_1	0.1111
p.P394Q	TCGA-EE-A183	SKCM	TCGA	SPDNGE	DEG_Kelch_Keap1_1	0.0556
p.P402H	TCGA-EE-A2GE	SKCM	TCGA	SPDNGE	DEG_Kelch_Keap1_1	0.2778
p.E398K	DO225215	BRCA	ICGC	SPDNGE	DEG_Kelch_Keap1_1	0.1667
p.E398K	DO227836	BRCA	ICGC	SPDNGE	DEG_Kelch_Keap1_1	0.1667
p.T395M	DO222960	BTCA	ICGC	SPDNGE	DEG_Kelch_Keap1_1	0.0833
p.P397T	DO229041	LICA	ICGC	SPDNGE	DEG_Kelch_Keap1_1	0.1389
p.Q416L	DO25426	LUAD	ICGC	SPDNGE	DEG_Kelch_Keap1_1	0.1389
p.P401H	DO38016	SKCM	ICGC	SPDNGE	DEG_Kelch_Keap1_1	0.25
p.G395D	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	SPDNGE	DEG_Kelch_Keap1_1	0.0833
p.G395D	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	SPDNGE	DEG_Kelch_Keap1_1	0.0833
p.G411E	SIDM01198	Burkitt's Lymphoma	GDSC	SPDNGE	DEG_Kelch_Keap1_1	0.2778
p.R399Q	SIDM00889	Cervical Carcinoma	GDSC	SPDNGE	DEG_Kelch_Keap1_1	0.1944
p.R399Q	C-33-A	cervix	COSMIC	SPDNGE	DEG_Kelch_Keap1_1	0.1944
p.W394C	SIDM00596	Endometrial Carcinoma	GDSC	SPDNGE	DEG_Kelch_Keap1_1	0.0556
p.W394C	HEC-1	endometrium	COSMIC	SPDNGE	DEG_Kelch_Keap1_1	0.0556
p.P408L	SIDM00140	Melanoma	GDSC	SPDNGE	DEG_Kelch_Keap1_1	0.7582
p.P408L	COLO-792	skin	COSMIC	SPDNGE	DEG_Kelch_Keap1_1	0.7582
p.P394L	ACH-000968	Skin Cancer	CCLE	SPDNGE	DEG_Kelch_Keap1_1	0.0556
p.P394L	COLO-792	skin	COSMIC	SPDNGE	DEG_Kelch_Keap1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6NUN9	Zinc finger protein 746	DEG_Kelch_Keap1_1	404:409	SPDNGE	KEAP1	0.8746	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons