DegronMD - Q6NWY9(PRPF40B)

PRPF40B

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q218E	TCGA-4Z-AA7W	BLCA	TCGA	PGPTPVPT	DEG_SCF_FBW7_1	206:213	Mutation rewiring degron network	0.1944
p.Q218K	TCGA-E7-A4IJ	BLCA	TCGA	PGPTPVPT	DEG_SCF_FBW7_1	206:213	Mutation rewiring degron network	0.1944
p.D219N	DO6302	CESC	ICGC	PGPTPVPT	DEG_SCF_FBW7_1	206:213	Mutation rewiring degron network	0.1667
p.V198L	DO228971	LICA	ICGC	PGPTPVPT	DEG_SCF_FBW7_1	206:213	Mutation rewiring degron network	0.1111
p.G208C	DO232224	PBCA	ICGC	PGPTPVPT	DEG_SCF_FBW7_1	206:213	Mutation altering degron motif	0.76
p.L209H	DO219503	SKCM	ICGC	PGPTPVPT	DEG_SCF_FBW7_1	206:213	Mutation altering degron motif	0.7313
p.G208D	DO43202	UCEC	ICGC	PGPTPVPT	DEG_SCF_FBW7_1	206:213	Mutation altering degron motif	0.7198
p.D219Y	DO42472	UCEC	ICGC	PGPTPVPT	DEG_SCF_FBW7_1	206:213	Mutation rewiring degron network	0.1667
p.P223S	SIDM00189	Melanoma	GDSC	PGPTPVPT	DEG_SCF_FBW7_1	206:213	Mutation rewiring degron network	0.0556
p.P223S	ACH-002098	Skin Cancer	CCLE	PGPTPVPT	DEG_SCF_FBW7_1	206:213	Mutation rewiring degron network	0.0556
p.P223S	CP67-MEL	skin	COSMIC	PGPTPVPT	DEG_SCF_FBW7_1	206:213	Mutation rewiring degron network	0.0556
p.P197S	SF126	central nervous system	COSMIC	PGPTPVPT	DEG_SCF_FBW7_1	206:213	Mutation rewiring degron network	0.0833
p.P201S	CP67-MEL	skin	COSMIC	PGPTPVPT	DEG_SCF_FBW7_1	206:213	Mutation rewiring degron network	0.1944
p.P203S	SF126	central nervous system	COSMIC	PGPTPVPT	DEG_SCF_FBW7_1	206:213	Mutation rewiring degron network	0.25

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*NOTE: the Kaplan plots were collected from OncoLnc