DegronMD

Uniprot ID: Q6NWY9

Source protein: Pre-mRNA-processing factor 40 homolog B

Source gene: PRPF40B

Class: DEG_SCF_FBW7_1

Location: 206:213

E3 ligase: FBXW7

DEGRON score: 0.8204

ASA_SCORE: 85.525

COIL: 0.9415

CONS_SCORE: 0.2353

DSS_SCORE: 0.914

HELIX: 0.0205

FCONS_SCORE: 0.8571

RIG_SCORE: 0.511

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q218E	TCGA-4Z-AA7W	BLCA	TCGA	PGPTPVPT	DEG_SCF_FBW7_1	0.1944
p.Q218K	TCGA-E7-A4IJ	BLCA	TCGA	PGPTPVPT	DEG_SCF_FBW7_1	0.1944
p.D219N	DO6302	CESC	ICGC	PGPTPVPT	DEG_SCF_FBW7_1	0.1667
p.V198L	DO228971	LICA	ICGC	PGPTPVPT	DEG_SCF_FBW7_1	0.1111
p.G208C	DO232224	PBCA	ICGC	PGPTPVPT	DEG_SCF_FBW7_1	0.76
p.L209H	DO219503	SKCM	ICGC	PGPTPVPT	DEG_SCF_FBW7_1	0.7313
p.G208D	DO43202	UCEC	ICGC	PGPTPVPT	DEG_SCF_FBW7_1	0.7198
p.D219Y	DO42472	UCEC	ICGC	PGPTPVPT	DEG_SCF_FBW7_1	0.1667
p.P223S	SIDM00189	Melanoma	GDSC	PGPTPVPT	DEG_SCF_FBW7_1	0.0556
p.P223S	ACH-002098	Skin Cancer	CCLE	PGPTPVPT	DEG_SCF_FBW7_1	0.0556
p.P223S	CP67-MEL	skin	COSMIC	PGPTPVPT	DEG_SCF_FBW7_1	0.0556
p.P197S	SF126	central_nervous_system	COSMIC	PGPTPVPT	DEG_SCF_FBW7_1	0.0833
p.P201S	CP67-MEL	skin	COSMIC	PGPTPVPT	DEG_SCF_FBW7_1	0.1944
p.P203S	SF126	central_nervous_system	COSMIC	PGPTPVPT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6NWY9	Pre-mRNA-processing factor 40 homolog B	DEG_SCF_FBW7_1	206:213	PGPTPVPT	FBXW7	0.8204	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons