DegronMD - Q6NXE6(ARMC6)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q23L	TCGA-86-A456	LUAD	TCGA	IGCTPTST	DEG_SCF_FBW7_1	15:22	Mutation rewiring degron network	0.3056
p.R30H	TCGA-A5-A0G2	UCEC	TCGA	IGCTPTST	DEG_SCF_FBW7_1	15:22	Mutation rewiring degron network	0.1111
p.R30H	DO233888	GACA	ICGC	IGCTPTST	DEG_SCF_FBW7_1	15:22	Mutation rewiring degron network	0.1111
p.R30H	DO41235	UCEC	ICGC	IGCTPTST	DEG_SCF_FBW7_1	15:22	Mutation rewiring degron network	0.1111
p.R30H	SIDM00216	Colorectal Carcinoma	GDSC	IGCTPTST	DEG_SCF_FBW7_1	15:22	Mutation rewiring degron network	0.1111
p.R30H	SIDM00217	Colorectal Carcinoma	GDSC	IGCTPTST	DEG_SCF_FBW7_1	15:22	Mutation rewiring degron network	0.1111
p.R30H	ACH-000989	Colon/Colorectal Cancer	CCLE	IGCTPTST	DEG_SCF_FBW7_1	15:22	Mutation rewiring degron network	0.1111
p.R30H	ACH-000999	Colon/Colorectal Cancer	CCLE	IGCTPTST	DEG_SCF_FBW7_1	15:22	Mutation rewiring degron network	0.1111
p.R30H	SNU-175	large intestine	COSMIC	IGCTPTST	DEG_SCF_FBW7_1	15:22	Mutation rewiring degron network	0.1111
p.R30H	SNU-1040	large intestine	COSMIC	IGCTPTST	DEG_SCF_FBW7_1	15:22	Mutation rewiring degron network	0.1111
p.S14Y	TCGA-AP-A1E0	UCEC	TCGA	IGCTPTST	DEG_SCF_FBW7_1	15:22	Mutation rewiring degron network	0.3056
p.S14Y	DO43154	UCEC	ICGC	IGCTPTST	DEG_SCF_FBW7_1	15:22	Mutation rewiring degron network	0.3056
p.S28F	TCGA-CN-6994	HNSC	TCGA	IGCTPTST	DEG_SCF_FBW7_1	15:22	Mutation rewiring degron network	0.1667
p.T20A	DO234181	ESAD	ICGC	IGCTPTST	DEG_SCF_FBW7_1	15:22	Mutation altering degron motif	0.6028
p.R13C	DO45526	LUSC	ICGC	IGCTPTST	DEG_SCF_FBW7_1	15:22	Mutation rewiring degron network	0.2778
p.G16S	DO27881	ORCA	ICGC	IGCTPTST	DEG_SCF_FBW7_1	15:22	Mutation altering degron motif	0.5882
p.S11C	DO47767	STAD	ICGC	IGCTPTST	DEG_SCF_FBW7_1	15:22	Mutation blocking phosphorylation signal	0.6667
p.R30C	SIDM00216	Colorectal Carcinoma	GDSC	IGCTPTST	DEG_SCF_FBW7_1	15:22	Mutation rewiring degron network	0.1111
p.R30C	ACH-000989	Colon/Colorectal Cancer	CCLE	IGCTPTST	DEG_SCF_FBW7_1	15:22	Mutation rewiring degron network	0.1111
p.R30C	SNU-175	large intestine	COSMIC	IGCTPTST	DEG_SCF_FBW7_1	15:22	Mutation rewiring degron network	0.1111
p.C17W	SIDM00677	Colorectal Carcinoma	GDSC	IGCTPTST	DEG_SCF_FBW7_1	15:22	Mutation altering degron motif	0.5889
p.C17Y	SIDM01619	Endometrial Carcinoma	GDSC	IGCTPTST	DEG_SCF_FBW7_1	15:22	Mutation altering degron motif	0.5976
p.C17Y	ACH-000984	Endometrial/Uterine Cancer	CCLE	IGCTPTST	DEG_SCF_FBW7_1	15:22	Mutation altering degron motif	0.5976
p.T22P	ACH-000472	Head and Neck Cancer	CCLE	IGCTPTST	DEG_SCF_FBW7_1	15:22	Mutation altering degron motif	0.7031
p.R13H	ACH-001991	Primary	CCLE	IGCTPTST	DEG_SCF_FBW7_1	15:22	Mutation rewiring degron network	0.2778
p.R16C	KYSE-270	oesophagus	COSMIC	IGCTPTST	DEG_SCF_FBW7_1	15:22	Mutation altering degron motif	0.8301
p.R5H	SNU-1040	large intestine	COSMIC	IGCTPTST	DEG_SCF_FBW7_1	15:22	Mutation substituting flanking lysine	0.1667
p.R5H	SNU-175	large intestine	COSMIC	IGCTPTST	DEG_SCF_FBW7_1	15:22	Mutation substituting flanking lysine	0.1667
p.R5C	SNU-175	large intestine	COSMIC	IGCTPTST	DEG_SCF_FBW7_1	15:22	Mutation substituting flanking lysine	0.1667
p.A23V	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	IGCTPTST	DEG_SCF_FBW7_1	15:22	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARMC6

UniProt ID: Q6NXE6

Entrez ID: 93436

Protein name: Armadillo repeat-containing protein 6

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARMC6 in