DegronMD

Uniprot ID: Q6NXE6

Source protein: Armadillo repeat-containing protein 6

Source gene: ARMC6

Class: DEG_SCF_FBW7_1

Location: 15:22

E3 ligase: FBXW7

DEGRON score: 0.997

ASA_SCORE: 77.9

COIL: 0.872

CONS_SCORE: 0.3422

DSS_SCORE: 0.337

HELIX: 0.0629

FCONS_SCORE: 0.8965

RIG_SCORE: 0.7017

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R16C	KYSE-270	oesophagus	COSMIC	IGCTPTST	DEG_SCF_FBW7_1	0.8301
p.T22P	ACH-000472	Head and Neck Cancer	CCLE	IGCTPTST	DEG_SCF_FBW7_1	0.7031
p.S11C	DO47767	STAD	ICGC	IGCTPTST	DEG_SCF_FBW7_1	0.6667
p.T20A	DO234181	ESAD	ICGC	IGCTPTST	DEG_SCF_FBW7_1	0.6028
p.C17Y	SIDM01619	Endometrial Carcinoma	GDSC	IGCTPTST	DEG_SCF_FBW7_1	0.5976
p.C17Y	ACH-000984	Endometrial/Uterine Cancer	CCLE	IGCTPTST	DEG_SCF_FBW7_1	0.5976
p.C17W	SIDM00677	Colorectal Carcinoma	GDSC	IGCTPTST	DEG_SCF_FBW7_1	0.5889
p.G16S	DO27881	ORCA	ICGC	IGCTPTST	DEG_SCF_FBW7_1	0.5882
p.Q23L	TCGA-86-A456	LUAD	TCGA	IGCTPTST	DEG_SCF_FBW7_1	0.3056
p.S14Y	TCGA-AP-A1E0	UCEC	TCGA	IGCTPTST	DEG_SCF_FBW7_1	0.3056
p.S14Y	DO43154	UCEC	ICGC	IGCTPTST	DEG_SCF_FBW7_1	0.3056
p.A23V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	IGCTPTST	DEG_SCF_FBW7_1	0.3056
p.R13C	DO45526	LUSC	ICGC	IGCTPTST	DEG_SCF_FBW7_1	0.2778
p.R13H	ACH-001991	Primary	CCLE	IGCTPTST	DEG_SCF_FBW7_1	0.2778
p.S28F	TCGA-CN-6994	HNSC	TCGA	IGCTPTST	DEG_SCF_FBW7_1	0.1667
p.R5H	SNU-1040	large_intestine	COSMIC	IGCTPTST	DEG_SCF_FBW7_1	0.1667
p.R5H	SNU-175	large_intestine	COSMIC	IGCTPTST	DEG_SCF_FBW7_1	0.1667
p.R5C	SNU-175	large_intestine	COSMIC	IGCTPTST	DEG_SCF_FBW7_1	0.1667
p.R30H	TCGA-A5-A0G2	UCEC	TCGA	IGCTPTST	DEG_SCF_FBW7_1	0.1111
p.R30H	DO233888	GACA	ICGC	IGCTPTST	DEG_SCF_FBW7_1	0.1111
p.R30H	DO41235	UCEC	ICGC	IGCTPTST	DEG_SCF_FBW7_1	0.1111
p.R30H	SIDM00216	Colorectal Carcinoma	GDSC	IGCTPTST	DEG_SCF_FBW7_1	0.1111
p.R30H	SIDM00217	Colorectal Carcinoma	GDSC	IGCTPTST	DEG_SCF_FBW7_1	0.1111
p.R30H	ACH-000989	Colon/Colorectal Cancer	CCLE	IGCTPTST	DEG_SCF_FBW7_1	0.1111
p.R30H	ACH-000999	Colon/Colorectal Cancer	CCLE	IGCTPTST	DEG_SCF_FBW7_1	0.1111

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Drug responses associated with ARMC6 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of IGCTPTST

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6NXE6	Armadillo repeat-containing protein 6	DEG_SCF_FBW7_1	15:22	IGCTPTST	FBXW7	0.997	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IGCTPTST

Degron related mutations and impact score

Drug responses associated with ARMC6 mutations

All proteins holding degron of IGCTPTST