DegronMD

Uniprot ID: Q6NXE6

Source protein: Armadillo repeat-containing protein 6

Source gene: ARMC6

Class: DEG_SCF_FBW7_1

Location: 15:22

E3 ligase: FBXW7

DEGRON score: 0.997

ASA_SCORE: 77.9

COIL: 0.872

CONS_SCORE: 0.3422

DSS_SCORE: 0.337

HELIX: 0.0629

FCONS_SCORE: 0.8965

RIG_SCORE: 0.7017

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q23L	TCGA-86-A456	LUAD	TCGA	IGCTPTST	DEG_SCF_FBW7_1	0.3056
p.R30H	TCGA-A5-A0G2	UCEC	TCGA	IGCTPTST	DEG_SCF_FBW7_1	0.1111
p.R30H	DO233888	GACA	ICGC	IGCTPTST	DEG_SCF_FBW7_1	0.1111
p.R30H	DO41235	UCEC	ICGC	IGCTPTST	DEG_SCF_FBW7_1	0.1111
p.R30H	SIDM00216	Colorectal Carcinoma	GDSC	IGCTPTST	DEG_SCF_FBW7_1	0.1111
p.R30H	SIDM00217	Colorectal Carcinoma	GDSC	IGCTPTST	DEG_SCF_FBW7_1	0.1111
p.R30H	ACH-000989	Colon/Colorectal Cancer	CCLE	IGCTPTST	DEG_SCF_FBW7_1	0.1111
p.R30H	ACH-000999	Colon/Colorectal Cancer	CCLE	IGCTPTST	DEG_SCF_FBW7_1	0.1111
p.R30H	SNU-175	large_intestine	COSMIC	IGCTPTST	DEG_SCF_FBW7_1	0.1111
p.R30H	SNU-1040	large_intestine	COSMIC	IGCTPTST	DEG_SCF_FBW7_1	0.1111
p.S14Y	TCGA-AP-A1E0	UCEC	TCGA	IGCTPTST	DEG_SCF_FBW7_1	0.3056
p.S14Y	DO43154	UCEC	ICGC	IGCTPTST	DEG_SCF_FBW7_1	0.3056
p.S28F	TCGA-CN-6994	HNSC	TCGA	IGCTPTST	DEG_SCF_FBW7_1	0.1667
p.T20A	DO234181	ESAD	ICGC	IGCTPTST	DEG_SCF_FBW7_1	0.6028
p.R13C	DO45526	LUSC	ICGC	IGCTPTST	DEG_SCF_FBW7_1	0.2778
p.G16S	DO27881	ORCA	ICGC	IGCTPTST	DEG_SCF_FBW7_1	0.5882
p.S11C	DO47767	STAD	ICGC	IGCTPTST	DEG_SCF_FBW7_1	0.6667
p.R30C	SIDM00216	Colorectal Carcinoma	GDSC	IGCTPTST	DEG_SCF_FBW7_1	0.1111
p.R30C	ACH-000989	Colon/Colorectal Cancer	CCLE	IGCTPTST	DEG_SCF_FBW7_1	0.1111
p.R30C	SNU-175	large_intestine	COSMIC	IGCTPTST	DEG_SCF_FBW7_1	0.1111
p.C17W	SIDM00677	Colorectal Carcinoma	GDSC	IGCTPTST	DEG_SCF_FBW7_1	0.5889
p.C17Y	SIDM01619	Endometrial Carcinoma	GDSC	IGCTPTST	DEG_SCF_FBW7_1	0.5976
p.C17Y	ACH-000984	Endometrial/Uterine Cancer	CCLE	IGCTPTST	DEG_SCF_FBW7_1	0.5976
p.T22P	ACH-000472	Head and Neck Cancer	CCLE	IGCTPTST	DEG_SCF_FBW7_1	0.7031
p.R13H	ACH-001991	Primary	CCLE	IGCTPTST	DEG_SCF_FBW7_1	0.2778
p.R16C	KYSE-270	oesophagus	COSMIC	IGCTPTST	DEG_SCF_FBW7_1	0.8301
p.R5H	SNU-1040	large_intestine	COSMIC	IGCTPTST	DEG_SCF_FBW7_1	0.1667
p.R5H	SNU-175	large_intestine	COSMIC	IGCTPTST	DEG_SCF_FBW7_1	0.1667
p.R5C	SNU-175	large_intestine	COSMIC	IGCTPTST	DEG_SCF_FBW7_1	0.1667
p.A23V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	IGCTPTST	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IGCTPTST

Degron related mutations and impact score

Drug responses associated with ARMC6 mutations

All proteins holding degron of IGCTPTST

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6NXE6	Armadillo repeat-containing protein 6	DEG_SCF_FBW7_1	15:22	IGCTPTST	FBXW7	0.997	More...