DegronMD - Q6NXP0(EFCAB12)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G17V	TCGA-55-7724	LUAD	TCGA	PSKTPINE	DEG_SCF_FBW7_2	20:27	Mutation rewiring degron network	0.25
p.G17V	DO45373	LUAD	ICGC	PSKTPINE	DEG_SCF_FBW7_2	20:27	Mutation rewiring degron network	0.25
p.G17E	TCGA-CV-7254	HNSC	TCGA	PSKTPINE	DEG_SCF_FBW7_2	20:27	Mutation rewiring degron network	0.25
p.G17E	DO14168	HNSC	ICGC	PSKTPINE	DEG_SCF_FBW7_2	20:27	Mutation rewiring degron network	0.25
p.K22E	DO8264	COAD	ICGC	PSKTPINE	DEG_SCF_FBW7_2	20:27	Mutation altering degron motif	0.591
p.D33V	DO23521	LIRI	ICGC	PSKTPINE	DEG_SCF_FBW7_2	20:27	Mutation rewiring degron network	0.1667
p.K22T	SIDM00107	Melanoma	GDSC	PSKTPINE	DEG_SCF_FBW7_2	20:27	Mutation altering degron motif	0.6195
p.K22T	ACH-000425	Skin Cancer	CCLE	PSKTPINE	DEG_SCF_FBW7_2	20:27	Mutation altering degron motif	0.6195
p.K22T	ACH-002004	Skin Cancer	CCLE	PSKTPINE	DEG_SCF_FBW7_2	20:27	Mutation altering degron motif	0.6195
p.K22T	UACC-62	skin	COSMIC	PSKTPINE	DEG_SCF_FBW7_2	20:27	Mutation altering degron motif	0.6195
p.S21C	SIDM00210	Ovarian Carcinoma	GDSC	PSKTPINE	DEG_SCF_FBW7_2	20:27	Mutation altering degron motif	0.643
p.S21C	SIDM00878	Breast Carcinoma	GDSC	PSKTPINE	DEG_SCF_FBW7_2	20:27	Mutation altering degron motif	0.643
p.P20L	SIDM00971	Breast Carcinoma	GDSC	PSKTPINE	DEG_SCF_FBW7_2	20:27	Mutation altering degron motif	0.6471
p.P20L	ZR-75-30	breast	COSMIC	PSKTPINE	DEG_SCF_FBW7_2	20:27	Mutation altering degron motif	0.6471
p.V37I	SIDM00214	Colorectal Carcinoma	GDSC	PSKTPINE	DEG_SCF_FBW7_2	20:27	Mutation rewiring degron network	0.0556
p.V37I	ACH-000955	Colon/Colorectal Cancer	CCLE	PSKTPINE	DEG_SCF_FBW7_2	20:27	Mutation rewiring degron network	0.0556
p.V37I	SNU-407	large intestine	COSMIC	PSKTPINE	DEG_SCF_FBW7_2	20:27	Mutation rewiring degron network	0.0556

Kaplan plot for EFCAB12 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EFCAB12

UniProt ID: Q6NXP0

Entrez ID: 90288

Protein name: EF-hand calcium-binding domain-containing protein 12

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EFCAB12 in