DegronMD

Uniprot ID: Q6NXP0

Source protein: EF-hand calcium-binding domain-containing protein 12

Source gene: EFCAB12

Class: DEG_SCF_FBW7_2

Location: 20:27

E3 ligase: FBXW7

DEGRON score: 0.5386

ASA_SCORE: 81.8875

COIL: 0.7094

CONS_SCORE: 0.3182

DSS_SCORE: 0.2166

HELIX: 0.271

FCONS_SCORE: 0.7008

RIG_SCORE: 0.7169

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G17V	TCGA-55-7724	LUAD	TCGA	PSKTPINE	DEG_SCF_FBW7_2	0.25
p.G17V	DO45373	LUAD	ICGC	PSKTPINE	DEG_SCF_FBW7_2	0.25
p.G17E	TCGA-CV-7254	HNSC	TCGA	PSKTPINE	DEG_SCF_FBW7_2	0.25
p.G17E	DO14168	HNSC	ICGC	PSKTPINE	DEG_SCF_FBW7_2	0.25
p.K22E	DO8264	COAD	ICGC	PSKTPINE	DEG_SCF_FBW7_2	0.591
p.D33V	DO23521	LIRI	ICGC	PSKTPINE	DEG_SCF_FBW7_2	0.1667
p.K22T	SIDM00107	Melanoma	GDSC	PSKTPINE	DEG_SCF_FBW7_2	0.6195
p.K22T	ACH-000425	Skin Cancer	CCLE	PSKTPINE	DEG_SCF_FBW7_2	0.6195
p.K22T	ACH-002004	Skin Cancer	CCLE	PSKTPINE	DEG_SCF_FBW7_2	0.6195
p.K22T	UACC-62	skin	COSMIC	PSKTPINE	DEG_SCF_FBW7_2	0.6195
p.S21C	SIDM00210	Ovarian Carcinoma	GDSC	PSKTPINE	DEG_SCF_FBW7_2	0.643
p.S21C	SIDM00878	Breast Carcinoma	GDSC	PSKTPINE	DEG_SCF_FBW7_2	0.643
p.P20L	SIDM00971	Breast Carcinoma	GDSC	PSKTPINE	DEG_SCF_FBW7_2	0.6471
p.P20L	ZR-75-30	breast	COSMIC	PSKTPINE	DEG_SCF_FBW7_2	0.6471
p.V37I	SIDM00214	Colorectal Carcinoma	GDSC	PSKTPINE	DEG_SCF_FBW7_2	0.0556
p.V37I	ACH-000955	Colon/Colorectal Cancer	CCLE	PSKTPINE	DEG_SCF_FBW7_2	0.0556
p.V37I	SNU-407	large_intestine	COSMIC	PSKTPINE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6NXP0	EF-hand calcium-binding domain-containing protein 12	DEG_SCF_FBW7_2	20:27	PSKTPINE	FBXW7	0.5386	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons