DegronMD - Q6NYC8(PPP1R18)

PPP1R18

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R210Q	TCGA-EY-A1G8	UCEC	TCGA	PGETPERS	DEG_SCF_FBW7_1	196:203	Mutation rewiring degron network	0.1389
p.R210Q	DO43578	UCEC	ICGC	PGETPERS	DEG_SCF_FBW7_1	196:203	Mutation rewiring degron network	0.1389
p.S203N	DO228263	MALY	ICGC	PGETPERS	DEG_SCF_FBW7_1	196:203	Mutation altering degron motif	0.818
p.E188K	DO218900	SKCA	ICGC	PGETPERS	DEG_SCF_FBW7_1	196:203	Mutation rewiring degron network	0.1111
p.R202Q	SIDM00386	Ewing's Sarcoma	GDSC	PGETPERS	DEG_SCF_FBW7_1	196:203	Mutation altering degron motif	0.6218
p.R202Q	SIDM00515	Melanoma	GDSC	PGETPERS	DEG_SCF_FBW7_1	196:203	Mutation altering degron motif	0.6218
p.R202Q	MHH-ES-1	bone	COSMIC	PGETPERS	DEG_SCF_FBW7_1	196:203	Mutation altering degron motif	0.6218
p.R202Q	COLO-800	skin	COSMIC	PGETPERS	DEG_SCF_FBW7_1	196:203	Mutation altering degron motif	0.6218
p.R193G	SIDM00482	Chronic Myelogenous Leukemia	GDSC	PGETPERS	DEG_SCF_FBW7_1	196:203	Mutation rewiring degron network	0.25
p.R193G	ACH-002302	Leukemia	CCLE	PGETPERS	DEG_SCF_FBW7_1	196:203	Mutation rewiring degron network	0.25
p.R193G	RPMI-8866	haematopoietic and lymphoid tissue	COSMIC	PGETPERS	DEG_SCF_FBW7_1	196:203	Mutation rewiring degron network	0.25
p.R210G	SIDM00118	Colorectal Carcinoma	GDSC	PGETPERS	DEG_SCF_FBW7_1	196:203	Mutation rewiring degron network	0.1389
p.R210G	SIDM01760	Rhabdomyosarcoma	GDSC	PGETPERS	DEG_SCF_FBW7_1	196:203	Mutation rewiring degron network	0.1389
p.R210G	HCC2998	large intestine	COSMIC	PGETPERS	DEG_SCF_FBW7_1	196:203	Mutation rewiring degron network	0.1389

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*NOTE: the Kaplan plots were collected from OncoLnc