DegronMD

Uniprot ID: Q6NYC8

Source protein: Phostensin

Source gene: PPP1R18

Class: DEG_SCF_FBW7_1

Location: 196:203

E3 ligase: FBXW7

DEGRON score: 0.9859

ASA_SCORE: 98.8

COIL: 0.8704

CONS_SCORE: 0.8308

DSS_SCORE: 0.4691

HELIX: 0.0871

FCONS_SCORE: 1.1389

RIG_SCORE: 0.6467

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R210Q	TCGA-EY-A1G8	UCEC	TCGA	PGETPERS	DEG_SCF_FBW7_1	0.1389
p.R210Q	DO43578	UCEC	ICGC	PGETPERS	DEG_SCF_FBW7_1	0.1389
p.S203N	DO228263	MALY	ICGC	PGETPERS	DEG_SCF_FBW7_1	0.818
p.E188K	DO218900	SKCA	ICGC	PGETPERS	DEG_SCF_FBW7_1	0.1111
p.R202Q	SIDM00386	Ewing's Sarcoma	GDSC	PGETPERS	DEG_SCF_FBW7_1	0.6218
p.R202Q	SIDM00515	Melanoma	GDSC	PGETPERS	DEG_SCF_FBW7_1	0.6218
p.R202Q	MHH-ES-1	bone	COSMIC	PGETPERS	DEG_SCF_FBW7_1	0.6218
p.R202Q	COLO-800	skin	COSMIC	PGETPERS	DEG_SCF_FBW7_1	0.6218
p.R193G	SIDM00482	Chronic Myelogenous Leukemia	GDSC	PGETPERS	DEG_SCF_FBW7_1	0.25
p.R193G	ACH-002302	Leukemia	CCLE	PGETPERS	DEG_SCF_FBW7_1	0.25
p.R193G	RPMI-8866	haematopoietic_and_lymphoid_tissue	COSMIC	PGETPERS	DEG_SCF_FBW7_1	0.25
p.R210G	SIDM00118	Colorectal Carcinoma	GDSC	PGETPERS	DEG_SCF_FBW7_1	0.1389
p.R210G	SIDM01760	Rhabdomyosarcoma	GDSC	PGETPERS	DEG_SCF_FBW7_1	0.1389
p.R210G	HCC2998	large_intestine	COSMIC	PGETPERS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6NYC8	Phostensin	DEG_SCF_FBW7_1	196:203	PGETPERS	FBXW7	0.9859	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons