DegronMD - Q6P047(C8orf74)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T228N	TCGA-17-Z014	LUAD	TCGA	ERQELESLI	DEG_APCC_DBOX_1	214:222	Mutation rewiring degron network	0.1667
p.A204T	TCGA-A5-A0G2	UCEC	TCGA	ERQELESLI	DEG_APCC_DBOX_1	214:222	Mutation rewiring degron network	0.0556
p.A204T	DO41235	UCEC	ICGC	ERQELESLI	DEG_APCC_DBOX_1	214:222	Mutation rewiring degron network	0.0556
p.E217A	TCGA-A5-A2K5	UCEC	TCGA	ERQELESLI	DEG_APCC_DBOX_1	214:222	Mutation altering degron motif	0.659
p.E217A	DO41379	UCEC	ICGC	ERQELESLI	DEG_APCC_DBOX_1	214:222	Mutation altering degron motif	0.659
p.A207V	TCGA-AA-3831	COAD	TCGA	ERQELESLI	DEG_APCC_DBOX_1	214:222	Mutation rewiring degron network	0.1389
p.A207V	DO8538	COAD	ICGC	ERQELESLI	DEG_APCC_DBOX_1	214:222	Mutation rewiring degron network	0.1389
p.I222V	DO228483	BRCA	ICGC	ERQELESLI	DEG_APCC_DBOX_1	214:222	Mutation altering degron motif	0.5965
p.I222V	DO229480	LAML	ICGC	ERQELESLI	DEG_APCC_DBOX_1	214:222	Mutation altering degron motif	0.5965
p.I222V	DO229489	LAML	ICGC	ERQELESLI	DEG_APCC_DBOX_1	214:222	Mutation altering degron motif	0.5965
p.I222V	DO228941	LICA	ICGC	ERQELESLI	DEG_APCC_DBOX_1	214:222	Mutation altering degron motif	0.5965
p.Q229H	DO228986	LICA	ICGC	ERQELESLI	DEG_APCC_DBOX_1	214:222	Mutation rewiring degron network	0.1389
p.Q208P	DO220891	MELA	ICGC	ERQELESLI	DEG_APCC_DBOX_1	214:222	Mutation rewiring degron network	0.1667
p.R215G	DO229140	THCA	ICGC	ERQELESLI	DEG_APCC_DBOX_1	214:222	Mutation altering degron motif	0.7568
p.Q216H	SIDM00210	Ovarian Carcinoma	GDSC	ERQELESLI	DEG_APCC_DBOX_1	214:222	Mutation altering degron motif	0.647
p.Q216H	SIDM00382	Glioblastoma	GDSC	ERQELESLI	DEG_APCC_DBOX_1	214:222	Mutation altering degron motif	0.647
p.Q216H	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	ERQELESLI	DEG_APCC_DBOX_1	214:222	Mutation altering degron motif	0.647
p.Q216H	SIDM00641	Burkitt's Lymphoma	GDSC	ERQELESLI	DEG_APCC_DBOX_1	214:222	Mutation altering degron motif	0.647
p.Q216H	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	ERQELESLI	DEG_APCC_DBOX_1	214:222	Mutation altering degron motif	0.647

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C8orf74

UniProt ID: Q6P047

Entrez ID: 203076

Protein name: Uncharacterized protein C8orf74

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C8orf74 in