DegronMD

Uniprot ID: Q6P047

Source protein: Uncharacterized protein C8orf74

Source gene: C8orf74

Class: DEG_APCC_DBOX_1

Location: 214:222

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8247

ASA_SCORE: 74.3778

COIL: 0.1106

CONS_SCORE: 0.4591

DSS_SCORE: 0.168

HELIX: 0.8842

FCONS_SCORE: 1.4088

RIG_SCORE: 0.8088

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T228N	TCGA-17-Z014	LUAD	TCGA	ERQELESLI	DEG_APCC_DBOX_1	0.1667
p.A204T	TCGA-A5-A0G2	UCEC	TCGA	ERQELESLI	DEG_APCC_DBOX_1	0.0556
p.A204T	DO41235	UCEC	ICGC	ERQELESLI	DEG_APCC_DBOX_1	0.0556
p.E217A	TCGA-A5-A2K5	UCEC	TCGA	ERQELESLI	DEG_APCC_DBOX_1	0.659
p.E217A	DO41379	UCEC	ICGC	ERQELESLI	DEG_APCC_DBOX_1	0.659
p.A207V	TCGA-AA-3831	COAD	TCGA	ERQELESLI	DEG_APCC_DBOX_1	0.1389
p.A207V	DO8538	COAD	ICGC	ERQELESLI	DEG_APCC_DBOX_1	0.1389
p.I222V	DO228483	BRCA	ICGC	ERQELESLI	DEG_APCC_DBOX_1	0.5965
p.I222V	DO229480	LAML	ICGC	ERQELESLI	DEG_APCC_DBOX_1	0.5965
p.I222V	DO229489	LAML	ICGC	ERQELESLI	DEG_APCC_DBOX_1	0.5965
p.I222V	DO228941	LICA	ICGC	ERQELESLI	DEG_APCC_DBOX_1	0.5965
p.Q229H	DO228986	LICA	ICGC	ERQELESLI	DEG_APCC_DBOX_1	0.1389
p.Q208P	DO220891	MELA	ICGC	ERQELESLI	DEG_APCC_DBOX_1	0.1667
p.R215G	DO229140	THCA	ICGC	ERQELESLI	DEG_APCC_DBOX_1	0.7568
p.Q216H	SIDM00210	Ovarian Carcinoma	GDSC	ERQELESLI	DEG_APCC_DBOX_1	0.647
p.Q216H	SIDM00382	Glioblastoma	GDSC	ERQELESLI	DEG_APCC_DBOX_1	0.647
p.Q216H	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	ERQELESLI	DEG_APCC_DBOX_1	0.647
p.Q216H	SIDM00641	Burkitt's Lymphoma	GDSC	ERQELESLI	DEG_APCC_DBOX_1	0.647
p.Q216H	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	ERQELESLI	DEG_APCC_DBOX_1	0.647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P047	Uncharacterized protein C8orf74	DEG_APCC_DBOX_1	214:222	ERQELESLI	APC,CDC20,FZR1	0.8247	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons