DegronMD - Q6P050(FBXL22)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G188E	DO219773	UCEC	ICGC	ARRGLGSLR	DEG_APCC_DBOX_1	170:178	Mutation rewiring degron network	0.0556
p.R171L	SIDM00151	Ovarian Carcinoma	GDSC	ARRGLGSLR	DEG_APCC_DBOX_1	170:178	Mutation altering degron motif	0.8428
p.R171L	ACH-000966	Ovarian Cancer	CCLE	ARRGLGSLR	DEG_APCC_DBOX_1	170:178	Mutation altering degron motif	0.8428
p.G165A	SIDM00613	Glioblastoma	GDSC	ARRGLGSLR	DEG_APCC_DBOX_1	170:178	Mutation rewiring degron network	0.1944
p.G165A	ACH-000231	Brain Cancer	CCLE	ARRGLGSLR	DEG_APCC_DBOX_1	170:178	Mutation rewiring degron network	0.1944
p.G165A	KALS-1	central nervous system	COSMIC	ARRGLGSLR	DEG_APCC_DBOX_1	170:178	Mutation rewiring degron network	0.1944
p.A168V	ACH-000990	Endometrial/Uterine Cancer	CCLE	ARRGLGSLR	DEG_APCC_DBOX_1	170:178	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons